Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q08380 LGALS3BP
| Class:Id | ReferenceGeneProduct:149505 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-585 added on Fri February 6 2015 |
| _displayName | UniProt:Q08380 LGALS3BP |
| _timestamp | 2024-11-03 20:19:54 |
| chain | signal peptide:1-18 chain:19-585 |
| checksum | C488C2E99D77435B |
| comment | FUNCTION Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.SUBUNIT Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).INTERACTION Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Galectin-3-binding protein alternativeName: Basement membrane autoantigen p105 alternativeName: Lectin galactoside-binding soluble 3-binding protein alternativeName: Mac-2-binding protein shortName: MAC2BP shortName: Mac-2 BP alternativeName: Tumor-associated antigen 90K |
| geneName | LGALS3BP M2BP |
| identifier | Q08380 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell adhesion Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LGALS3BP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962391] ENSEMBL:ENSG00000108679 LGALS3BP [Homo sapiens] |
| secondaryIdentifier | LG3BP_HUMAN A0A0S2Z3Y1 Q7M4S0 Q9UCH8 Q9UCH9 Q9UCI0 |
| sequenceLength | 585 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8848882] LGALS3BP [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8848916] LGALS3BP [platelet dense granule lumen] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q08380 LGALS3BP (149505)
