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Details on Person UniProt:Q13554-6 CAMK2B
| Class:Id | ReferenceIsoform:149258 |
|---|---|
| _chainChangeLog | chain:1-666 added on Fri February 6 2015 |
| _displayName | UniProt:Q13554-6 CAMK2B |
| _timestamp | 2025-02-21 18:37:56 |
| chain | chain:1-666 |
| checksum | 8CACFC3E392C3857 |
| comment | FUNCTION Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.SUBUNIT CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref.20). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2B activation by Ca(2+) (By similarity).INTERACTION In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.ALTERNATIVE PRODUCTS The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.TISSUE SPECIFICITY Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.INDUCTION Activity is induced in skeletal muscle during exercise.DOMAIN The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.PTM Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. |
| description | recommendedName: Calcium/calmodulin-dependent protein kinase type II subunit beta shortName: CaM kinase II subunit beta shortName: CaMK-II subunit beta ecNumber evidence="14"2.7.11.17 |
| geneName | CAMK2B CAM2 CAMK2 CAMKB |
| identifier | Q13554 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Actin-binding Alternative splicing ATP-binding Calmodulin-binding Cytoplasm Cytoskeleton Developmental protein Differentiation Intellectual disability Kinase Membrane Neurogenesis Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Sarcoplasmic reticulum Serine/threonine-protein kinase Synapse Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CAMK2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990786] ENSEMBL:ENSG00000058404 CAMK2B [Homo sapiens] |
| secondaryIdentifier | KCC2B_HUMAN A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599 Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4 |
| sequenceLength | 666 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13554-6 |
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No pathways have been reviewed or authored by UniProt:Q13554-6 CAMK2B (149258)
