Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8BK63 Csnk1a1
| Class:Id | ReferenceGeneProduct:149204 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-337 added on Fri February 6 2015;initiator methionine:1 for 149204 removed on Fri Nov 03 2023;initiator methionine: for 149204 added on Fri Nov 03 2023;initiator methionine: for 149204 removed on Fri Aug 15 2025;initiator methionine:1 for 149204 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8BK63 Csnk1a1 |
| _timestamp | 2025-08-15 21:53:44 |
| chain | initiator methionine:1 chain:2-337 |
| checksum | 1B2085AE33CAFAC2 |
| comment | FUNCTION Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Can phosphorylate a large number of proteins (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (PubMed:21930935). May play a role in segregating chromosomes during mitosis (By similarity). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34615873).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with the Axin complex (By similarity). Interacts with TUT1, leading to TUT1 phosphorylation (By similarity). Interacts with FAM83A, FAM83B, FAM83C, FAM83D, FAM83E, FAM83F, FAM83G and FAM83H (via DUF1669) (PubMed:35931121). Interaction with FAM83H recruits CSNK1A1 to keratin filaments (By similarity).SUBCELLULAR LOCATION Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton.ALTERNATIVE PRODUCTS Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Casein kinase I isoform alpha shortName: CKI-alpha ecNumber: 2.7.11.1 alternativeName: CK1 |
| geneName | Csnk1a1 |
| identifier | Q8BK63 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing ATP-binding Cell cycle Cell division Cell projection Centromere Chromosome Cytoplasm Cytoskeleton Kinase Kinetochore Mitosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Wnt signaling pathway |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Csnk1a1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KC1A_MOUSE Q3UIL0 Q64506 Q80XI2 Q99LY3 |
| sequenceLength | 337 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:149205] UniProt:Q8BK63-2 Csnk1a1 [Mus musculus] [ReferenceIsoform:410156] UniProt:Q8BK63-1 Csnk1a1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:205762] CKIalpha [cytosol] [Mus musculus] [EntityWithAccessionedSequence:5632506] Csnk1a1 [cilium] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8BK63 Csnk1a1 (149204)
