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Details on Person UniProt:Q9BX67 JAM3
| Class:Id | ReferenceGeneProduct:149037 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Sat February 7 2015;chain:32-310 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BX67 JAM3 |
| _timestamp | 2024-11-03 20:10:24 |
| chain | signal peptide:1-31 chain:32-310 chain:32- |
| checksum | CE39ADF33EA1DAB9 |
| comment | FUNCTION Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity).FUNCTION Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.SUBUNIT Interacts with ITGAM (PubMed:12208882, PubMed:15194813). Interacts with GORASP2 (By similarity).INTERACTION Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945).SUBCELLULAR LOCATION Detected on round and elongated spermatids (at protein level) (PubMed:15372036). Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).DOMAIN The Ig-like V-type domain mediates interaction with JAM2.PTM Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by pro-inflammatory factors.PTM S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the immunoglobulin superfamily. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Junctional adhesion molecule C shortName: JAM-C alternativeName: JAM-2 alternativeName: Junctional adhesion molecule 3 shortName: JAM-3 component recommendedName: fullName evidence="20"Soluble form of JAM-C shortName evidence="20"sJAM-C /component |
| geneName | JAM3 UNQ859/PRO1868 |
| identifier | Q9BX67 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Angiogenesis Cell adhesion Cell junction Cell membrane Differentiation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Lipoprotein Membrane Palmitate Proteomics identification Reference proteome Secreted Signal Spermatogenesis Tight junction Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | JAM3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004175] ENSEMBL:ENSG00000166086 JAM3 [Homo sapiens] |
| secondaryIdentifier | JAM3_HUMAN B3KWG9 Q8WWL8 Q96FL1 |
| sequenceLength | 310 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969231] UniProt:Q9BX67-1 JAM3 [Homo sapiens] [ReferenceIsoform:8969232] UniProt:Q9BX67-2 JAM3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197895] JAM3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BX67 JAM3 (149037)
