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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of DAG and IP3 signaling

Class:IdPathwayDiagram:1489514
_displayNameDiagram of DAG and IP3 signaling
_timestamp2025-09-19 09:42:41
created[InstanceEdit:1489515] Rothfels, K, 2011-08-15
height1001
modified[InstanceEdit:1502548] Rothfels, K, 2011-08-23
[InstanceEdit:1567004] Rothfels, K, 2011-09-06
[InstanceEdit:1986606] Rothfels, K, 2011-11-11
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8948633] Rothfels, Karen, 2016-11-14
[InstanceEdit:8948634] Rothfels, Karen, 2016-11-14
[InstanceEdit:8980524] Jupe, Steve, 2017-02-27
[InstanceEdit:8980525] Jupe, Steve, 2017-02-27
[InstanceEdit:9016831] Jassal, Bijay, 2017-08-16
[InstanceEdit:9615317] Orlic-Milacic, Marija, 2018-08-01
[InstanceEdit:9615318] Orlic-Milacic, Marija, 2018-08-01
[InstanceEdit:9615329] Orlic-Milacic, Marija, 2018-08-01
[InstanceEdit:9615332] Orlic-Milacic, Marija, 2018-08-01
[InstanceEdit:9615400] Orlic-Milacic, Marija, 2018-08-02
[InstanceEdit:9628299] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9628302] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9628308] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9628309] Orlic-Milacic, Marija, 2018-11-07
[InstanceEdit:9644873] Jassal, Bijay, 2019-04-26
[InstanceEdit:9644874] Jassal, Bijay, 2019-04-26
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9668585] Orlic-Milacic, Marija, 2019-11-28
[InstanceEdit:9860021] D'Eustachio, Peter, 2024-01-29
[InstanceEdit:9947397] D'Eustachio, Peter, 2025-05-05
[InstanceEdit:9966345] Stephan, Ralf, 2025-09-19
[InstanceEdit:9966347] Stephan, Ralf, 2025-09-19
representedPathway[Pathway:1489509] DAG and IP3 signaling [Homo sapiens]
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<org.gk.render.RenderableChemical id="457" reactomeId="114519" position="972 43" bounds="952 28 41 31" textPosition="956 32"> <Properties> <displayName>DAG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="458" reactomeId="70106" position="923 99" bounds="911 88 25 23" textPosition="911 88"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="463" reactomeId="70106" position="1601 518" bounds="1589 507 25 23" textPosition="1589 507" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="265" reactomeId="74448" points="1247 350, 1341 350" position="1341 350" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="111" stoichiometry="4" points="1191 349" /> <Input id="332" points="1227 302" /> </Inputs> <Outputs> <Output id="110" /> </Outputs> <Properties> <displayName>Calcium binds calmodulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="266" reactomeId="111966" points="1407 151, 1406 151, 1338 61" position="1406 151" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" points="1434 54" /> <Input id="110" points="1407 336" /> </Inputs> <Outputs> <Output id="113" /> </Outputs> <Inhibitors> <Inhibitor id="305" points="1467 142" /> </Inhibitors> <Properties> <displayName>GRK2 binds CALM1:4Ca2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="267" reactomeId="111924" points="2336 238, 2406 301, 2483 365" position="2406 301" lineWidth="1.0"> <Inputs> <Input id="123" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Properties> <displayName>PKA catalytic subunit translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="111916" points="2363 548, 2385 511, 2382 468" position="2385 511" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="132" stoichiometry="2" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> <Properties> <displayName>Dimerization of p-S133-CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="269" reactomeId="111919" points="2399 758, 2386 690, 2392 650" position="2386 690" lineWidth="1.0"> <Inputs> <Input id="127" points="2415 825" /> <Input id="136" points="2448 785" /> </Inputs> <Outputs> <Output id="132" points="2362 576" /> <Output id="135" points="2457 608" /> </Outputs> <Catalysts> <Catalyst id="336" points="2460 671" /> </Catalysts> <Properties> <displayName>PKA phosphorylates CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="271" reactomeId="111930" points="1775 142, 1825 143, 1864 143" position="1825 143" lineWidth="1.0"> <Inputs> <Input id="119" /> </Inputs> <Outputs> <Output id="120" points="1889 168" /> <Output id="122" points="1894 120" /> </Outputs> <Catalysts> <Catalyst id="121" points="1821 58" /> </Catalysts> <Inhibitors> <Inhibitor id="335" points="1713 248" /> </Inhibitors> <Activators> <Activator id="110" points="1429 336" /> </Activators> <Properties> <displayName>Adenylate cyclase produces cAMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="272" reactomeId="112282" points="1822 373, 1895 368, 1988 364" position="1895 368" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="337" /> </Inputs> <Outputs> <Output id="338" points="2048 373" /> <Output id="339" points="2020 349" /> </Outputs> <Activators> <Activator id="340" points="1844 328" /> </Activators> <Properties> <displayName>CAMK4 enters the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="273" reactomeId="111915" points="2200 676, 2177 707, 2169 736" position="2177 707" lineWidth="1.0"> <Inputs> <Input id="341" points="2215 660" /> <Input id="342" points="2162 672" /> </Inputs> <Outputs> <Output id="134" points="2142 737" /> <Output id="130" points="2195 736" /> </Outputs> <Catalysts> <Catalyst id="341" points="2233 660, 2236 683" /> </Catalysts> <Properties> <displayName>CAMK4 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="274" reactomeId="111912" points="2387 762, 2363 689, 2371 638" position="2363 689" lineWidth="1.0"> <Inputs> <Input id="127" points="2413 825" /> <Input id="136" points="2448 788" /> </Inputs> <Outputs> <Output id="132" points="2359 576" /> <Output id="135" points="2457 603" /> </Outputs> <Catalysts> <Catalyst id="130" points="2305 715" /> </Catalysts> <Properties> <displayName>CaMK4 phosphorylates CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="111913" points="2073 417, 2092 418, 2131 418" position="2092 418" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="338" points="2075 391" /> <Input id="343" points="2006 437" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>Calmodulin binds CAMK4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="111955" points="1495 561, 1538 561, 1559 561" position="1538 561" lineWidth="1.0"> <Inputs> <Input id="141" points="1479 575" /> <Input id="142" points="1471 542" /> </Inputs> <Outputs> <Output id="138" points="1582 577" /> <Output id="463" points="1589 533" /> </Outputs> <Catalysts> <Catalyst id="333" points="1538 494" /> </Catalysts> <Properties> <displayName>cAMP hydrolysis by Cam-PDE 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="277" reactomeId="111956" points="1367 469, 1408 469, 1492 469" position="1408 469" lineWidth="1.0"> <Inputs> <Input id="139" /> </Inputs> <Outputs> <Output id="333" /> </Outputs> <Activators> <Activator id="110" points="1407 364" /> </Activators> <Properties> <displayName>Calmodulin activates Cam-PDE 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="278" reactomeId="167686" points="798 44, 840 44, 874 43" position="840 44" lineWidth="1.0"> <Inputs> <Input id="279" points="778 44" /> <Input id="280" points="772 92" /> </Inputs> <Outputs> <Output id="457" points="949 43" /> <Output id="281" points="876 117" /> <Output id="458" points="912 85" /> </Outputs> <Catalysts> <Catalyst id="283" points="699 16, 748 5" /> </Catalysts> <Properties> <displayName>Active PLCG1 hydrolyses PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="284" reactomeId="198314" points="1090 139, 1140 139, 1172 139" position="1140 139" lineWidth="1.0"> <Inputs> <Input id="285" points="1044 114" /> <Input id="286" stoichiometry="3" points="1052 167" /> </Inputs> <Outputs> <Output id="287" points="1208 118" /> <Output id="288" stoichiometry="3" points="1200 166" /> </Outputs> <Catalysts> <Catalyst id="285" points="1081 90, 1140 90" /> </Catalysts> <Activators> <Activator id="457" points="996 43, 1065 43" /> </Activators> <Properties> <displayName>DAG stimulates protein kinase C-delta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="296" reactomeId="169680" points="860 218, 848 289, 873 288" position="848 289" lineWidth="1.0"> <Inputs> <Input id="281" stoichiometry="4" points="874 151" /> <Input id="456" points="793 267" /> </Inputs> <Outputs> <Output id="298" /> </Outputs> <Catalysts> <Catalyst id="456" points="816 289" /> </Catalysts> <Properties> <displayName>IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="299" reactomeId="169683" points="922 354, 1043 351, 1123 349" position="1043 351" lineWidth="1.0"> <Inputs> <Input id="300" /> </Inputs> <Outputs> <Output id="111" /> </Outputs> <Catalysts> <Catalyst id="298" points="972 313" /> </Catalysts> <Inhibitors> <Inhibitor id="306" points="915 430" /> </Inhibitors> <Activators> <Activator id="281" points="902 151, 1036 222" /> </Activators> <Properties> <displayName>IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="301" reactomeId="111970" points="1472 182, 1514 182, 1542 182" position="1514 182" lineWidth="1.0"> <Inputs> <Input id="302" points="1458 215" /> <Input id="112" points="1439 54" /> </Inputs> <Outputs> <Output id="303" points="1583 182" /> <Output id="304" points="1561 216" /> </Outputs> <Catalysts> <Catalyst id="305" points="1525 156" /> </Catalysts> <Properties> <displayName>PKC phosphorylates GRK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="330" reactomeId="8951727" points="1991 211, 2020 210, 2065 180" position="2020 210" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="120" stoichiometry="4" points="1933 194" /> <Input id="331" points="1937 226" /> </Inputs> <Outputs> <Output id="307" /> </Outputs> <Properties> <displayName>cAMP binds PKA tetramer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="344" reactomeId="9619125" points="2184 458, 2181 494, 2185 525" position="2181 494" lineWidth="1.0"> <Inputs> <Input id="128" points="2184 439" /> <Input id="345" points="2203 464" /> </Inputs> <Outputs> <Output id="346" points="2207 531" /> <Output id="341" points="2223 618" /> </Outputs> <Catalysts> <Catalyst id="347" points="2145 485" /> </Catalysts> <Properties> <displayName>CaMKK phosphorylates CAMK4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="352" reactomeId="9619127" points="1644 377, 1685 378, 1721 377" position="1685 378" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="353" points="1597 347" /> <Input id="354" points="1600 390" /> </Inputs> <Outputs> <Output id="337" /> </Outputs> <Properties> <displayName>CAMK4 binds KPNA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="365" reactomeId="444792" points="1643 721, 1874 719, 1984 779" position="1874 719" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="366" /> </Inputs> <Outputs> <Output id="367" /> </Outputs> <Activators> <Activator id="368" points="1753 671" /> </Activators> <Properties> <displayName>Calmodulin-bound CaMKII-gamma enters the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="377" reactomeId="442725" points="1243 446, 1228 489, 1233 580" position="1228 489" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="110" stoichiometry="12" points="1388 364" /> <Input id="378" points="1179 435" /> </Inputs> <Outputs> <Output id="379" /> </Outputs> <Properties> <displayName>CaMKII binds activated calmodulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="380" reactomeId="9617583" points="1302 658, 1355 676, 1395 693" position="1355 676" lineWidth="1.0"> <Inputs> <Input id="379" points="1256 622" /> <Input id="381" stoichiometry="12" points="1258 692" /> </Inputs> <Outputs> <Output id="382" points="1488 669" /> <Output id="383" stoichiometry="12" points="1411 736" /> </Outputs> <Catalysts> <Catalyst id="379" points="1301 606, 1358 612" /> </Catalysts> <Properties> <displayName>CaMKII autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="388" reactomeId="9618834" points="2026 779, 2021 693, 1966 644" position="2021 693" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="367" /> </Inputs> <Outputs> <Output id="343" stoichiometry="12" points="1973 465" /> <Output id="389" points="1961 676" /> </Outputs> <Properties> <displayName>Activated calmodulin dissociates from CaMKII-gamma</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="390" reactomeId="9618863" points="2012 554, 2031 583, 2068 596" position="2031 583" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="343" points="1978 465" /> <Input id="391" points="2007 605" /> </Inputs> <Outputs> <Output id="392" /> </Outputs> <Properties> <displayName>CaMKK binds activated calmodulin in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="397" reactomeId="442749" points="2104 576, 2100 550, 2099 514" position="2100 550" lineWidth="1.0"> <Inputs> <Input id="392" points="2107 596" /> <Input id="398" points="2127 576" /> </Inputs> <Outputs> <Output id="399" points="2123 516" /> <Output id="347" points="2091 494" /> </Outputs> <Catalysts> <Catalyst id="392" points="2095 596, 2065 563" /> </Catalysts> <Properties> <displayName>CaMKK autophosphorylates in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="400" points="2521 634, 2505 413" position="2513 523" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="336" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="449" reactomeId="9668558" points="2051 121, 2081 120, 2130 115" position="2081 120" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="450" points="1996 107" /> <Input id="451" points="2038 97" /> </Inputs> <Outputs> <Output id="452" /> </Outputs> <Properties> <displayName>NBEA binds PRKAR2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="455" reactomeId="111925" points="2138 158, 2187 158, 2252 158" position="2187 158" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="307" /> </Inputs> <Outputs> <Output id="123" stoichiometry="2" points="2296 190" /> <Output id="124" points="2274 123" /> </Outputs> <Catalysts> <Catalyst id="307" points="2138 173, 2187 191" /> </Catalysts> <Properties> <displayName>cAMP induces dissociation of inactive PKA tetramers</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of DAG and IP3 signaling (1489514)
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