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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of MyD88-independent TLR4 cascade

Class:IdPathwayDiagram:1486164
_displayNameDiagram of MyD88-independent TLR4 cascade
_timestamp2024-02-29 14:11:06
created[InstanceEdit:1486162] Shamovsky, V, 2011-08-12
height1249
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1843854] Shamovsky, V, 2011-10-27
[InstanceEdit:1986611] Shamovsky, V, 2011-11-11
[InstanceEdit:2201368] Shamovsky, V, 2012-04-19
[InstanceEdit:2206278] Shamovsky, V, 2012-04-26
[InstanceEdit:2206371] Shamovsky, V, 2012-04-26
[InstanceEdit:2213018] Shamovsky, V, 2012-04-27
[InstanceEdit:2248853] Shamovsky, V, 2012-05-15
[InstanceEdit:2248860] Shamovsky, V, 2012-05-15
[InstanceEdit:2299711] Shamovsky, V, 2012-06-01
[InstanceEdit:2559579] Shamovsky, V, 2012-11-02
[InstanceEdit:2562515] Shamovsky, V, 2012-11-05
[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
[InstanceEdit:2569085] Shamovsky, V, 2012-11-12
[InstanceEdit:2581443] Shamovsky, V, 2012-11-13
[InstanceEdit:2584235] Shamovsky, V, 2012-11-14
[InstanceEdit:2584576] Shamovsky, V, 2012-11-14
[InstanceEdit:3288225] Shamovsky, V, 2013-04-15
[InstanceEdit:5362530] Shamovsky, V, 2014-04-16
[InstanceEdit:5602772] Shamovsky, Veronica, 2014-06-24
[InstanceEdit:5608040] Shamovsky, Veronica, 2014-07-15
[InstanceEdit:8877183] Orlic-Milacic, Marija, 2016-06-21
[InstanceEdit:8877184] Orlic-Milacic, Marija, 2016-06-21
[InstanceEdit:8877505] Orlic-Milacic, Marija, 2016-06-22
[InstanceEdit:9014561] Shamovsky, Veronica, 2017-08-01
[InstanceEdit:9014707] Shamovsky, Veronica, 2017-08-02
[InstanceEdit:9017521] Shamovsky, Veronica, 2017-08-21
[InstanceEdit:9029371] Jupe, Steve, 2017-11-16
[InstanceEdit:9767876] Shamovsky, Veronica, 2022-03-01
[InstanceEdit:9768148] Shamovsky, Veronica, 2022-03-04
[InstanceEdit:9828414] Shamovsky, Veronica, 2023-02-14
[InstanceEdit:9830263] Shamovsky, Veronica, 2023-03-02
[InstanceEdit:9863355] Shamovsky, Veronica, 2024-02-29
representedPathway[Pathway:166166] MyD88-independent TLR4 cascade [Homo sapiens]
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<Properties> <displayName>TBK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="4878" reactomeId="9823899" position="1475 496" bounds="1418 457 115 79" textPosition="1418 458" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4880" reactomeId="113592" position="1592 312" bounds="1572 297 40 31" textPosition="1576 301"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4881" reactomeId="29370" position="1596 379" bounds="1576 364 41 31" textPosition="1580 368" /> <org.gk.render.RenderableComplex id="4882" reactomeId="9824884" position="1459 400" bounds="1394 361 130 79" textPosition="1394 362" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4889" reactomeId="113592" position="1649 520" bounds="1629 505 40 31" textPosition="1633 509" /> <org.gk.render.RenderableChemical id="4890" reactomeId="29370" position="1656 690" bounds="1636 675 41 31" textPosition="1640 679" /> <org.gk.render.RenderableComplex id="4891" reactomeId="9823900" position="1468 703" bounds="1403 664 130 79" textPosition="1403 665" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4892" reactomeId="9823935" position="1453 611" bounds="1388 572 130 79" textPosition="1388 573" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="4894" reactomeId="9687907" position="1574 558" bounds="1553 547 42 23" textPosition="1553 547"> <Properties> <displayName>OPTN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4895" reactomeId="113592" position="1650 807" bounds="1630 792 40 31" textPosition="1634 796" /> <org.gk.render.RenderableComplex id="4952" reactomeId="9823938" position="1157 1034" bounds="1092 995 130 79" textPosition="1092 996" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4954" reactomeId="9823909" position="1317 1046" bounds="1252 1007 130 79" textPosition="1252 1008" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="4961" reactomeId="113595" position="925 130" bounds="913 119 25 23" textPosition="913 119"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="370" reactomeId="166175" points="562 148, 602 149, 643 166" position="602 149" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="368" points="531 158" /> <Input id="371" stoichiometry="2" points="504 136" /> </Inputs> <Outputs> <Output id="372" /> </Outputs> <Properties> <displayName>TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="381" reactomeId="166271" points="1547 829, 1549 846, 1530 855" position="1549 846" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="761" points="1536 823" /> <Input id="1108" stoichiometry="2" points="1572 806" /> </Inputs> <Outputs> <Output id="760" /> </Outputs> <Inhibitors> <Inhibitor id="4155" points="1564 844" /> </Inhibitors> <Properties> <displayName>IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="385" reactomeId="168921" points="76 341, 76 363, 76 441, 145 511" position="76 363" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="386" stoichiometry="2" points="66 297" /> <Input id="372" points="614 197, 127 274" /> </Inputs> <Outputs> <Output id="387" /> </Outputs> <Inhibitors> <Inhibitor id="2976" points="104 345" /> <Inhibitor id="2975" points="132 221, 33 239, 33 362" /> </Inhibitors> <Properties> <displayName>TRIF:activated TLR3/TLR4 complex recruits RIP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="602" reactomeId="168933" points="1699 958, 1699 996, 1684 1017" position="1699 996" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="599" stoichiometry="2" /> </Inputs> <Outputs> <Output id="603" /> </Outputs> <Properties> <displayName>Dimerization of phosphorylated IRF3/IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="604" reactomeId="177671" points="1674 1066, 1674 1079, 1671 1118" position="1674 1079" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="603" /> </Inputs> <Outputs> <Output id="605" /> </Outputs> <Properties> <displayName>Dimerized phospho-IRF3/IRF7 is transported to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1109" reactomeId="166245" points="1650 860, 1676 860, 1698 860" position="1676 860" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="4895" stoichiometry="6" points="1650 826" /> <Input id="760" points="1530 874" /> </Inputs> <Outputs> <Output id="1506" stoichiometry="6" points="1699 826" /> <Output id="599" stoichiometry="2" points="1698 909" /> <Output id="761" points="1536 777, 1591 755, 1729 754, 1731 860" /> </Outputs> <Catalysts> <Catalyst id="760" points="1530 881, 1675 879" /> </Catalysts> <Properties> <displayName>Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1122" reactomeId="168915" points="87 551, 39 566, 40 858, 128 858" position="40 858" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="1126" stoichiometry="2" points="69 512" /> <Input id="387" points="104 548" /> </Inputs> <Outputs> <Output id="763" /> </Outputs> <Catalysts> <Catalyst id="3248" points="90 897" /> </Catalysts> <Properties> <displayName>K63-linked ubiquitination of RIP1 bound to the activated TLR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1179" reactomeId="937029" points="168 948, 168 964, 173 983" position="168 964" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="614" points="156 948" /> <Input id="763" points="188 887" /> </Inputs> <Outputs> <Output id="1180" /> </Outputs> <Properties> <displayName>IKBKG subunit of IKK complex binds polyubiquinated RIP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1323" reactomeId="936985" points="804 154, 834 154, 861 173" position="834 154" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="1330" points="802 139" /> <Input id="372" points="750 169" /> </Inputs> <Outputs> <Output id="1324" /> </Outputs> <Inhibitors> <Inhibitor id="2975" points="190 183, 180 58, 834 59" /> </Inhibitors> <Properties> <displayName>Activated TLR4:TICAM1 recruits TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1335" reactomeId="936952" points="971 160, 962 1017, 883 1040" position="962 1017" lineWidth="1.0" lineColor="0 0 0" reactionType="Omitted Process"> <Inputs> <Input id="1324" points="941 173" /> <Input id="4961" stoichiometry="3" points="944 138" /> </Inputs> <Outputs> <Output id="1336" /> </Outputs> <Properties> <displayName>Auto ubiquitination of TRAF6 bound to the activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1341" reactomeId="936947" points="743 1106, 720 1106, 704 1098" position="720 1106" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2743" stoichiometry="2" points="753 1132" /> <Input id="1336" points="775 1089" /> <Input id="1395" stoichiometry="2" points="1481 1114, 806 1113" /> </Inputs> <Outputs> <Output id="1342" /> </Outputs> <Properties> <displayName>Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1351" reactomeId="936951" points="594 1117, 574 1117, 554 1117" position="574 1117" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1342" points="621 1098" /> <Input id="1352" stoichiometry="4" points="618 1136" /> </Inputs> <Outputs> <Output id="1353" points="530 1098" /> <Output id="1354" stoichiometry="4" points="526 1138" /> </Outputs> <Catalysts> <Catalyst id="1342" points="593 1087, 575 1096" /> </Catalysts> <Properties> <displayName>Activation of TAK1 complex bound to activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1357" reactomeId="937075" points="420 1023, 397 1011, 352 1010" position="397 1011" lineWidth="1.0" lineColor="0 0 0" reactionType="Dissociation"> <Inputs> <Input id="1353" /> </Inputs> <Outputs> <Output id="745" points="333 1028" /> <Output id="372" points="674 209" /> </Outputs> <Properties> <displayName>Phosphorylated TAK1 leaves activated TLR receptor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1498" interactionType="Activate" points="335 1085, 377 1123" position="356 1104" lineWidth="2.0"> <Inputs> <Input id="745" /> </Inputs> <Outputs> <Output id="1483" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1500" interactionType="Activate" points="291 1085, 259 1126" position="275 1105" lineWidth="2.0"> <Inputs> <Input id="745" /> </Inputs> <Outputs> <Output id="1484" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1502" interactionType="Activate" points="194 1054, 225 1126" position="209 1090" lineWidth="2.0"> <Inputs> <Input id="1180" /> </Inputs> <Outputs> <Output id="1484" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2243" reactomeId="2201338" points="784 101, 1045 101, 1045 159" position="1045 101" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2244" stoichiometry="2" points="747 91" /> <Input id="372" points="703 166" /> </Inputs> <Outputs> <Output id="2169" /> </Outputs> <Inhibitors> <Inhibitor id="2975" points="189 183, 177 43, 1044 43" /> </Inhibitors> <Properties> <displayName>TRAF3 binds TICAM1:activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2740" reactomeId="2213017" points="1091 138, 1133 138, 1165 162" position="1133 138" lineWidth="1.0" lineColor="0 0 0" reactionType="Omitted Process"> <Inputs> <Input id="2169" points="1069 159" /> <Input id="2742" points="1079 121" /> </Inputs> <Outputs> <Output id="2738" /> </Outputs> <Catalysts> <Catalyst id="2169" points="1106 165, 1122 158" /> </Catalysts> <Properties> <displayName>Auto-ubiquitination of TRAF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2974" reactomeId="2559568" points="106 192, 106 211, 132 211" position="106 211" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2923" points="87 169" /> <Input id="372" points="677 166, 654 81, 146 81" /> </Inputs> <Outputs> <Output id="2975" /> </Outputs> <Properties> <displayName>SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3136" reactomeId="2562541" points="156 588, 156 607, 193 630" position="156 607" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="387" points="162 568" /> <Input id="3137" stoichiometry="2" points="121 588" /> <Input id="3138" stoichiometry="2" points="119 617" /> </Inputs> <Outputs> <Output id="3139" /> </Outputs> <Inhibitors> <Inhibitor id="763" points="264 857, 311 857, 311 606" /> </Inhibitors> <Properties> <displayName>TLR4-induced ripoptosome assembly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3170" reactomeId="2562564" points="199 687, 174 704, 172 724" position="174 704" lineWidth="1.0" lineColor="0 0 0" reactionType="Transition"> <Inputs> <Input id="3139" /> </Inputs> <Outputs> <Output id="3171" points="133 738" /> <Output id="3172" points="200 735" /> </Outputs> <Catalysts> <Catalyst id="3139" points="164 681, 154 686" /> </Catalysts> <Properties> <displayName>Caspase-8 processing within TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3231" reactomeId="2569057" points="180 361, 181 375, 193 454" position="181 375" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2976" stoichiometry="4" points="153 345" /> <Input id="3232" points="198 314" /> </Inputs> <Outputs> <Output id="3235" /> </Outputs> <Properties> <displayName>RIP3 binds TRIF to mediate necroptosis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="3233" points="236 539, 283 539, 280 293, 271 293" position="281 416" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="387" /> </Inputs> <Outputs> <Output id="3232" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="4658" reactomeId="5362486" points="1226 141, 1249 142, 1272 154" position="1249 142" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4659" stoichiometry="2" points="1213 122" /> <Input id="2738" points="1211 162" /> </Inputs> <Outputs> <Output id="4437" /> </Outputs> <Properties> <displayName>TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4669" reactomeId="5362500" points="1402 142, 1422 142, 1444 157" position="1422 142" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="4437" points="1385 151" /> <Input id="4671" points="1391 130" /> </Inputs> <Outputs> <Output id="4656" /> </Outputs> <Properties> <displayName>TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4744" reactomeId="450358" points="1556 946, 1556 982, 1523 1101" position="1556 982" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1338" /> </Inputs> <Outputs> <Output id="1395" /> </Outputs> <Catalysts> <Catalyst id="4745" points="1478 1027, 1532 982" /> </Catalysts> <Properties> <displayName>Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="4746" points="850 1089, 868 1098, 1438 1095, 1450 1076" position="1153 1096" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1336" /> </Inputs> <Outputs> <Output id="4745" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableInteraction id="4795" interactionType="Activate" points="173 454, 158 447, 144 431" position="158 447" lineWidth="2.0"> <Inputs> <Input id="3235" /> </Inputs> <Outputs> <Output id="4793" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4797" interactionType="Activate" points="106 767, 106 782" position="106 774" lineWidth="2.0"> <Inputs> <Input id="3171" /> </Inputs> <Outputs> <Output id="4792" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="4873" reactomeId="9823932" points="1562 257, 1561 275, 1527 282" position="1561 275" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4874" stoichiometry="2" points="1581 223" /> <Input id="4656" points="1524 228" /> </Inputs> <Outputs> <Output id="4875" /> </Outputs> <Properties> <displayName>Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4876" reactomeId="9823910" points="1639 299, 1639 322, 1640 496, 1536 496" position="1639 322" lineWidth="1.0"> <Inputs> <Input id="4877" stoichiometry="2" points="1644 238" /> <Input id="4656" points="1533 228" /> </Inputs> <Outputs> <Output id="4878" /> </Outputs> <Properties> <displayName>Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4879" reactomeId="9824882" points="1545 331, 1546 349, 1547 365" position="1546 349" lineWidth="1.0"> <Inputs> <Input id="4875" points="1527 321" /> <Input id="4880" stoichiometry="2" points="1569 320" /> </Inputs> <Outputs> <Output id="4881" stoichiometry="2" points="1573 373" /> <Output id="4882" points="1527 374" /> </Outputs> <Properties> <displayName>IKKε (IKBKE) is phosphorylated within the activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4888" reactomeId="9823906" points="1652 566, 1653 609, 1655 637" position="1653 609" lineWidth="1.0"> <Inputs> <Input id="4889" stoichiometry="2" points="1650 539" /> <Input id="4878" points="1536 518" /> </Inputs> <Outputs> <Output id="4890" stoichiometry="2" points="1655 672" /> <Output id="4891" points="1536 680" /> </Outputs> <Activators> <Activator id="4892" points="1521 610" /> </Activators> <Properties> <displayName>TBK1 is phosphorylated within the activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4893" reactomeId="9823934" points="1536 557, 1535 575, 1521 582" position="1535 575" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4894" points="1550 557" /> <Input id="4878" points="1514 539" /> </Inputs> <Outputs> <Output id="4892" /> </Outputs> <Properties> <displayName>OPTN binds TBK1 within the activated TLR4 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4951" reactomeId="9823939" points="1415 968, 1416 989, 1235 989, 1225 996" position="1416 989" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="4875" points="1404 293, 1356 292, 1362 922" /> <Input id="1338" points="1538 931" /> </Inputs> <Outputs> <Output id="4952" /> </Outputs> <Properties> <displayName>IKKε (IKBKE) is ubiquitinated within the activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4953" reactomeId="9823904" points="1449 970, 1450 991, 1385 1019" position="1450 991" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="4878" points="1415 530, 1377 554, 1376 918" /> <Input id="1338" points="1538 932" /> </Inputs> <Outputs> <Output id="4954" /> </Outputs> <Properties> <displayName>TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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