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Details on Person UniProt:Q13601 KRR1
| Class:Id | ReferenceGeneProduct:148539 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-381 added on Fri February 6 2015;initiator methionine:1 for 148539 removed on Fri Nov 03 2023;initiator methionine: for 148539 added on Fri Nov 03 2023;initiator methionine: for 148539 removed on Fri Aug 15 2025;initiator methionine:1 for 148539 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q13601 KRR1 |
| _timestamp | 2025-08-15 21:08:20 |
| chain | initiator methionine:1 chain:2-381 |
| checksum | 8F242FCC36BF079B |
| comment | FUNCTION Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.SUBUNIT (Microbial infection) Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.INTERACTION (Microbial infection) Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR.ALTERNATIVE PRODUCTS Belongs to the KRR1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: KRR1 small subunit processome component homolog alternativeName: HIV-1 Rev-binding protein 2 alternativeName: KRR-R motif-containing protein 1 alternativeName: Rev-interacting protein 1 shortName: Rip-1 |
| geneName | KRR1 HRB2 |
| identifier | Q13601 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosome biogenesis RNA-binding rRNA processing Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KRR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002429] ENSEMBL:ENSG00000111615 KRR1 [Homo sapiens] |
| secondaryIdentifier | KRR1_HUMAN A0FIK6 A0JLP0 B2R989 E7EUQ0 Q8NEA8 Q8TC37 Q96AT5 |
| sequenceLength | 381 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977895] UniProt:Q13601-1 KRR1 [Homo sapiens] [ReferenceIsoform:8977896] UniProt:Q13601-2 KRR1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6790611] KRR1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13601 KRR1 (148539)
