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Details on Person PC is exchanged with PI by PITPNB

Class:Id	Reaction:1483219
_displayName	PC is exchanged with PI by PITPNB
_doRelease	TRUE
_timestamp	2024-02-12 20:10:59
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:9855941] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9855945] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[Complex:1524110] PC:PITPNB [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:426639] PI [endoplasmic reticulum membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:1483105] Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells [LiteratureReference:1483109] Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum [LiteratureReference:1483200] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine [LiteratureReference:1483223] Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms [LiteratureReference:1483130] Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association [LiteratureReference:1483188] Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol
modified	[InstanceEdit:1491769] Williams, MG, 2011-08-15 [InstanceEdit:1524116] Williams, MG, 2011-08-24 [InstanceEdit:1524171] Williams, MG, 2011-08-24 [InstanceEdit:1602450] Williams, MG, 2011-09-14 [InstanceEdit:1676083] Williams, MG, 2011-10-17 [InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9855942] D'Eustachio, Peter, 2023-12-08 [InstanceEdit:9860911] D'Eustachio, Peter, 2024-02-12
name	PC is exchanged with PI by PITPNB
output	[Complex:1524117] PI:PITPNB [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:426925] PC [endoplasmic reticulum membrane]
precedingEvent	[Reaction:1483211] PC:PITPNB is transported from the Golgi membrane to the ER membrane [Homo sapiens] [Reaction:1483087] PI is exchanged with PC by PITPNB [Homo sapiens] [Reaction:1482976] CDP-DAG is converted to PI by CDIPT [Homo sapiens] [Reaction:1483121] PA is converted to CDP-DAG by CDS1 [Homo sapiens] [Reaction:1482598] 1-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Homo sapiens] [Reaction:1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] [Homo sapiens] [Reaction:1482626] 2-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] [Homo sapiens] [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane [Homo sapiens] [Reaction:1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Homo sapiens] [Reaction:8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane [Homo sapiens] [Reaction:8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane [Homo sapiens] [Reaction:8867876] OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:9860910] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295212] R-HSA-1483219.3
structureModified	[InstanceEdit:9855942] D'Eustachio, Peter, 2023-12-08
summation	[Summation:1482923] At the ER membrane, phosphatidylcholine (PC) is exchanged fo...
(hasEvent)	[Pathway:1483196] PI and PC transport between ER and Golgi membranes [Homo sapiens]
(precedingEvent)	[Reaction:1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] [Homo sapiens] [Reaction:1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C [Homo sapiens] [Reaction:1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] [Homo sapiens] [Reaction:1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] [Homo sapiens] [Reaction:1483142] PC is transphosphatidylated to PG by PLD1-4/6 [Homo sapiens] [Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483186] PC is converted to PS by PTDSS1 [Homo sapiens] [Reaction:1483229] PI:PITPNB is transported from the ER membrane to the Golgi membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9863958] Update Tracker - [Reaction:1483219] PC is exchanged with PI by PITPNB - v88:[addCatalystActivity, modifyText]
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No pathways have been reviewed or authored by PC is exchanged with PI by PITPNB (1483219)