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Details on Person PA is dephosphorylated to DAG by LPIN

Class:Id	Reaction:1483203
_displayName	PA is dephosphorylated to DAG by LPIN
_doRelease	TRUE
_timestamp	2012-05-31 09:38:46
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500627] phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643903] phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:426755] PA [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:549163] Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns [LiteratureReference:549166] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
modified	[InstanceEdit:1484771] Williams, MG, 2011-08-12 [InstanceEdit:1500632] Williams, MG, 2011-08-19 [InstanceEdit:1592410] Williams, MG, 2011-09-09 [InstanceEdit:1602449] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2063939] Williams, MG, 2012-01-18 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PA is dephosphorylated to DAG by LPIN
output	[SimpleEntity:1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) [Homo sapiens] [Reaction:75886] glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] [Homo sapiens] [Reaction:549112] G3P is acylated to 1-acyl LPA by AGPAT6 [Homo sapiens] [Reaction:75883] DHRS7B reduces GO3P to HXDG3P [Homo sapiens] [BlackBoxEvent:163748] Transcriptional activation of AGPAT1 by ChREBP:MLX [Homo sapiens] [Reaction:1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] [Homo sapiens] [Reaction:1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294692] R-HSA-1483203.3
summation	[Summation:1482977] At the endoplasmic reticulum (ER) membrane, phosphatidate ph...
(hasEvent)	[Pathway:1483191] Synthesis of PC [Homo sapiens] [Pathway:1483213] Synthesis of PE [Homo sapiens]
(precedingEvent)	[Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Homo sapiens]
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No pathways have been reviewed or authored by PA is dephosphorylated to DAG by LPIN (1483203)