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Details on Person PCho and CTP are condensed to CDP-Cho by PCYT1 dimer

Class:Id	Reaction:1483081
_displayName	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
_doRelease	TRUE
_timestamp	2012-05-31 09:50:55
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524105] choline-phosphate cytidylyltransferase activity of PCYT1 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1524071] PCho [cytosol] [SimpleEntity:110614] CTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1483000] Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
modified	[InstanceEdit:1491770] Williams, MG, 2011-08-15 [InstanceEdit:1524116] Williams, MG, 2011-08-24 [InstanceEdit:1602490] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
output	[SimpleEntity:1524060] CDP-Cho [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:1483004] Cho is phosphorylated to PCho by CHK dimer [Homo sapiens] [Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483159] PCho is dephosphorylated to Cho by PHOSPHO1 [Homo sapiens] [Reaction:444433] Cho transports from the extracellular space to the cytosol [Homo sapiens] [Reaction:1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295182] R-HSA-1483081.2
summation	[Summation:1482821] At the endoplasmic reticulum (ER) membrane, active membrane-...
(hasEvent)	[Pathway:1483191] Synthesis of PC [Homo sapiens]
(precedingEvent)	[Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482973] CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane [Homo sapiens]
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No pathways have been reviewed or authored by PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (1483081)