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Details on Person Cho is phosphorylated to PCho by CHK dimer

Class:Id	Reaction:1483004
_displayName	Cho is phosphorylated to PCho by CHK dimer
_doRelease	TRUE
_timestamp	2012-05-31 09:50:55
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524073] choline kinase activity of CHK dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1483038] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:264618] Cho [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1483009] Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment [LiteratureReference:1483015] Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine
modified	[InstanceEdit:1491768] Williams, MG, 2011-08-15 [InstanceEdit:1524088] Williams, MG, 2011-08-24 [InstanceEdit:1602443] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cho is phosphorylated to PCho by CHK dimer
output	[SimpleEntity:1524071] PCho [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1483159] PCho is dephosphorylated to Cho by PHOSPHO1 [Homo sapiens] [Reaction:1483004] Cho is phosphorylated to PCho by CHK dimer [Homo sapiens] [Reaction:444433] Cho transports from the extracellular space to the cytosol [Homo sapiens] [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE [Homo sapiens] [Reaction:1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 [Homo sapiens] [Reaction:1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Homo sapiens] [Reaction:1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Homo sapiens] [Reaction:1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Homo sapiens] [Reaction:1482629] 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Homo sapiens] [Reaction:8952251] PLA2G15 hydrolyses LPC to GPCho and LCFA(-) [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295181] R-HSA-1483004.2
summation	[Summation:1483030] In the cytosol, choline kinase alpha subunit (CHKA) homodime...
(hasEvent)	[Pathway:1483191] Synthesis of PC [Homo sapiens]
(precedingEvent)	[Reaction:1483081] PCho and CTP are condensed to CDP-Cho by PCYT1 dimer [Homo sapiens] [Reaction:1483159] PCho is dephosphorylated to Cho by PHOSPHO1 [Homo sapiens]
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