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Details on Person UniProt:Q8N257 H2BC26
| Class:Id | ReferenceGeneProduct:148296 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-126 added on Fri February 6 2015;initiator methionine:1 for 148296 removed on Fri Nov 03 2023;initiator methionine: for 148296 added on Fri Nov 03 2023;initiator methionine: for 148296 removed on Fri Aug 15 2025;initiator methionine:1 for 148296 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8N257 H2BC26 |
| _timestamp | 2026-02-20 22:55:13 |
| chain | initiator methionine:1 chain:2-126 |
| checksum | F1E12FE400DCF25E |
| comment | FUNCTION Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.PTM Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:12757711). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.PTM GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).PTM ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (PubMed:34874266). H2BS6ADPr promotes recruitment of CHD1L (PubMed:34874266). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity).PTM Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.PTM Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.SIMILARITY Belongs to the histone H2B family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Histone H2B type 3-B alternativeName: H2B type 12 alternativeName: fullName evidence="29"H2B-clustered histone 26 alternativeName: fullName evidence="29"H2B.U histone 1 |
| geneName | H2BC26 H2BU1 HIST3H2BB |
| identifier | Q8N257 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ADP-ribosylation Chromosome Direct protein sequencing DNA-binding Glycoprotein Hydroxylation Isopeptide bond Methylation Nucleosome core Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | H2BC26 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994253] ENSEMBL:ENSG00000196890 H2BC26 [Homo sapiens] |
| secondaryIdentifier | H2B3B_HUMAN A4FU05 Q3ZCP6 Q5TA30 |
| sequenceLength | 126 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:181923] HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:977572] HIST3H2BB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:3364030] Ub-121-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4549249] AcK-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4568654] AcK13-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4568677] AcK6-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4568683] AcK21-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4568685] AcK16-HIST3H2BB [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6782555] Ub-HIST3H2BB [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3359496] ubiquitinylated lysine at 121 [ModifiedResidue:4549299] N6-acetyl-L-lysine at unknown position [ModifiedResidue:4568649] N6-acetyl-L-lysine at 6 [ModifiedResidue:4568655] N6-acetyl-L-lysine at 13 [ModifiedResidue:4568665] N6-acetyl-L-lysine at 21 [ModifiedResidue:4568694] N6-acetyl-L-lysine at 16 [GroupModifiedResidue:6782564] ubiquitinylated lysine (monoUb [nucleoplasm]) at 120 |
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No pathways have been reviewed or authored by UniProt:Q8N257 H2BC26 (148296)
