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Details on Person PE is hydrolyzed to 1-acyl LPE by PLA2[3]

Class:Id	Reaction:1482887
_displayName	PE is hydrolyzed to 1-acyl LPE by PLA2[3]
_doRelease	TRUE
_timestamp	2012-05-31 09:50:31
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524133] A2-type glycerophospholipase activity of PLA2(3) [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1500581] PE [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1482931] Structure and properties of a human non-pancreatic phospholipase A2 [LiteratureReference:1482657] Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 [LiteratureReference:1482805] Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
modified	[InstanceEdit:1484771] Williams, MG, 2011-08-12 [InstanceEdit:1491770] Williams, MG, 2011-08-15 [InstanceEdit:1524131] Williams, MG, 2011-08-24 [InstanceEdit:1602490] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2230933] D'Eustachio, P, 2012-05-05 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PE is hydrolyzed to 1-acyl LPE by PLA2[3]
output	[SimpleEntity:1498738] 1-acyl LPE [endoplasmic reticulum membrane] [SimpleEntity:1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:1483077] PE transports from the mitochondrial membrane to the ER [Homo sapiens] [Reaction:1483212] PS is decarboxylated to PE by PISD [Homo sapiens] [Reaction:1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) [Homo sapiens] [Reaction:1482667] 1-acyl LPE is acylated to PE by LPEAT [Homo sapiens] [Reaction:1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] [Homo sapiens] [Reaction:1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] [Homo sapiens] [Reaction:1482646] 2-acyl LPE is acylated to PE by LPEAT [Homo sapiens] [Reaction:1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] [Homo sapiens] [Reaction:1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C [Homo sapiens] [Reaction:1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Homo sapiens] [Reaction:1483190] PETA and CTP are condensed to CDP-ETA by PCY2 [Homo sapiens] [Reaction:1483203] PA is dephosphorylated to DAG by LPIN [Homo sapiens] [Reaction:1482777] TAG is hydrolyzed to DAG by PNPLA2/3 [Homo sapiens] [Reaction:1482654] 2-MAG is transacylated to DAG by PNPLA2/3 [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295158] R-HSA-1482887.2
summation	[Summation:1482812] At the endoplasmic reticulum (ER) membrane, phosphatidyletha...
(hasEvent)	[Pathway:1482839] Acyl chain remodelling of PE [Homo sapiens]
(precedingEvent)	[Reaction:1482571] 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Homo sapiens] [Reaction:1482667] 1-acyl LPE is acylated to PE by LPEAT [Homo sapiens]
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No pathways have been reviewed or authored by PE is hydrolyzed to 1-acyl LPE by PLA2[3] (1482887)