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Details on Person UniProt:Q92598-2 HSPH1
| Class:Id | ReferenceIsoform:148279 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-858 added on Fri February 6 2015;initiator methionine:1 for 148279 removed on Fri Nov 03 2023;initiator methionine: for 148279 added on Fri Nov 03 2023;initiator methionine: for 148279 removed on Fri Aug 15 2025;initiator methionine:1 for 148279 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q92598-2 HSPH1 |
| _timestamp | 2025-08-15 21:30:44 |
| chain | initiator methionine:1 chain:2-858 |
| checksum | D0E757970E340B56 |
| comment | FUNCTION Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).SUBUNIT Interacts with HSPA8/HSC70 (By similarity). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877).INTERACTION Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.PTM Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.SIMILARITY Belongs to the heat shock protein 70 family. |
| description | recommendedName: Heat shock protein 105 kDa alternativeName: Antigen NY-CO-25 alternativeName: Heat shock 110 kDa protein alternativeName: Heat shock protein family H member 1 |
| geneName | HSPH1 HSP105 HSP110 KIAA0201 |
| identifier | Q92598 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Direct protein sequencing Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Stress response |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HSPH1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:4793746] ENSEMBL:ENSG00000120694 HSPH1 [Homo sapiens] |
| secondaryIdentifier | HS105_HUMAN B4DYH1 O95739 Q5TBM6 Q5TBM7 Q5TBM8 Q9UPC4 |
| sequenceLength | 858 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q92598-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92598-2 HSPH1 (148279)
