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Details on Person TAG is hydrolyzed to DAG by PNPLA2/3

Class:Id	Reaction:1482777
_displayName	TAG is hydrolyzed to DAG by PNPLA2/3
_doRelease	TRUE
_timestamp	2012-05-31 09:48:40
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500645] triacylglycerol lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1500594] TAG [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1482692] Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities [LiteratureReference:1482706] A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis [LiteratureReference:1482888] Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
modified	[InstanceEdit:1484771] Williams, MG, 2011-08-12 [InstanceEdit:1500643] Williams, MG, 2011-08-19 [InstanceEdit:1529122] Williams, MG, 2011-08-25 [InstanceEdit:1602498] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2230933] D'Eustachio, P, 2012-05-05 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TAG is hydrolyzed to DAG by PNPLA2/3
output	[SimpleEntity:1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 [Homo sapiens] [Reaction:1482654] 2-MAG is transacylated to DAG by PNPLA2/3 [Homo sapiens] [Reaction:1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 [Homo sapiens] [Reaction:1482777] TAG is hydrolyzed to DAG by PNPLA2/3 [Homo sapiens] [Reaction:1482889] DAG is acylated to TAG by DGAT1/2 [Homo sapiens] [Reaction:1482777] TAG is hydrolyzed to DAG by PNPLA2/3 [Homo sapiens] [Reaction:1482654] 2-MAG is transacylated to DAG by PNPLA2/3 [Homo sapiens] [Reaction:5696448] AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295095] R-HSA-1482777.2
summation	[Summation:1482774] At the endoplasmic reticulum (ER) membrane, triacylglycerol ...
(hasEvent)	[Pathway:1482883] Acyl chain remodeling of DAG and TAG [Homo sapiens]
(precedingEvent)	[Reaction:1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 [Homo sapiens] [Reaction:1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 [Homo sapiens] [Reaction:1482889] DAG is acylated to TAG by DGAT1/2 [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Homo sapiens]
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No pathways have been reviewed or authored by TAG is hydrolyzed to DAG by PNPLA2/3 (1482777)