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Details on Person UniProt:O15488-5 GYG2
| Class:Id | ReferenceIsoform:148276 |
|---|---|
| _chainChangeLog | chain:1-501 added on Fri February 6 2015 |
| _displayName | UniProt:O15488-5 GYG2 |
| _timestamp | 2025-02-21 19:28:14 |
| chain | chain:1-501 |
| checksum | 8488A09D6E564693 |
| comment | FUNCTION Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.CATALYTIC ACTIVITY L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)CATALYTIC ACTIVITY [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)COFACTOR Glycan biosynthesis; glycogen biosynthesis.SUBUNIT Homodimer, tightly complexed to glycogen synthase.INTERACTION Localizes to glycogen granules (glycosomes) in the cytoplasm (By similarity). Cytosolic localization is dependent on the actin cytoskeleton (By similarity).ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Detected in liver (at protein level) (PubMed:9857012). Expressed preferentially in liver, heart, and pancreas (PubMed:9346895).PTM Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.MASS SPECTROMETRY Belongs to the glycosyltransferase 8 family. Glycogenin subfamily. |
| description | recommendedName: Glycogenin-2 shortName: GN-2 shortName: GN2 ecNumber evidence="7 8"2.4.1.186 |
| geneName | GYG2 |
| identifier | O15488 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Glycogen biosynthesis Glycoprotein Manganese Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GYG2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997182] ENSEMBL:ENSG00000056998 GYG2 [Homo sapiens] |
| secondaryIdentifier | GLYG2_HUMAN B7WNN6 O15485 O15486 O15487 O15489 O15490 |
| sequenceLength | 501 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O15488-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O15488-5 GYG2 (148276)
