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Details on Person 2-acyl LPS is acylated to PS by LPSAT

Class:Id	Reaction:1482691
_displayName	2-acyl LPS is acylated to PS by LPSAT
_doRelease	TRUE
_timestamp	2012-05-31 09:52:37
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524049] 2-acylglycerol-3-phosphate O-acyltransferase activity of LPSAT [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1498722] 2-acyl LPS [endoplasmic reticulum membrane] [SimpleEntity:1500578] acyl-CoA [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1482645] Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity [LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2
modified	[InstanceEdit:1491767] Williams, MG, 2011-08-15 [InstanceEdit:1524048] Williams, MG, 2011-08-24 [InstanceEdit:1601947] Williams, MG, 2011-09-13 [InstanceEdit:1602349] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	2-acyl LPS is acylated to PS by LPSAT
output	[SimpleEntity:1500646] PS [endoplasmic reticulum membrane] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10] [Homo sapiens] [Reaction:1483186] PC is converted to PS by PTDSS1 [Homo sapiens] [Reaction:1483089] PE is converted to PS by PTDSS2 [Homo sapiens] [Reaction:1482636] 1-acyl LPS is acylated to PS by LPSAT [Homo sapiens] [Reaction:1482691] 2-acyl LPS is acylated to PS by LPSAT [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295240] R-HSA-1482691.2
summation	[Summation:1482607] At the endoplasmic reticulum (ER) membrane, lysophospholipid...
(hasEvent)	[Pathway:1482801] Acyl chain remodelling of PS [Homo sapiens]
(precedingEvent)	[Reaction:1482771] PS is hydrolyzed to 1-acyl LPS by PLA2[9] [Homo sapiens] [Reaction:1482776] PS is hydrolyzed to 1-acyl LPS by PLA2G2A [Homo sapiens] [Reaction:1482897] PS is hydrolyzed to 2-acyl LPS by PLA2[10] [Homo sapiens] [BlackBoxEvent:1483170] PS transports from the ER membrane to the IM membrane [Homo sapiens]
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No pathways have been reviewed or authored by 2-acyl LPS is acylated to PS by LPSAT (1482691)