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Details on Person 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]

Class:Id	Reaction:1482685
_displayName	1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
_doRelease	TRUE
_timestamp	2012-05-31 09:43:24
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524022] phosphatidylcholine lysophospholipase A1 activity of PLA2(8) [cytosol]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1482693] The identification of a phospholipase B precursor in human neutrophils [LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms [LiteratureReference:1482518] Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 [LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
modified	[InstanceEdit:1491766] Williams, MG, 2011-08-15 [InstanceEdit:1524033] Williams, MG, 2011-08-24 [InstanceEdit:1602344] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2230935] D'Eustachio, P, 2012-05-05 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
output	[SimpleEntity:1498750] GPCho [cytosol] [SimpleEntity:1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294885] R-HSA-1482685.2
summation	[Summation:1482655] At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosp...
(hasEvent)	[Pathway:1483115] Hydrolysis of LPC [Homo sapiens]
(precedingEvent)	[Reaction:1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 [Homo sapiens]
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No pathways have been reviewed or authored by 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (1482685)