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Details on Person 1-acyl LPI is acylated to PI by MBOAT7

Class:Id	Reaction:1482598
_displayName	1-acyl LPI is acylated to PI by MBOAT7
_doRelease	TRUE
_timestamp	2012-05-31 09:37:03
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524032] 1-acylglycerol-3-phosphate O-acyltransferase activity of MBOAT7 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1498733] 1-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:1500578] acyl-CoA [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482673] Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol
modified	[InstanceEdit:1491767] Williams, MG, 2011-08-15 [InstanceEdit:1524033] Williams, MG, 2011-08-24 [InstanceEdit:1602347] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	1-acyl LPI is acylated to PI by MBOAT7
output	[SimpleEntity:426639] PI [endoplasmic reticulum membrane] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Homo sapiens] [Reaction:1482976] CDP-DAG is converted to PI by CDIPT [Homo sapiens] [Reaction:1482598] 1-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1482626] 2-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane [Homo sapiens] [Reaction:1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] [Homo sapiens] [Reaction:1482976] CDP-DAG is converted to PI by CDIPT [Homo sapiens] [Reaction:1482598] 1-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1482626] 2-acyl LPI is acylated to PI by MBOAT7 [Homo sapiens] [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294639] R-HSA-1482598.2
summation	[Summation:1482603] At the endoplasmic reticulum (ER) membrane, lysophospholipid...
(hasEvent)	[Pathway:1482922] Acyl chain remodelling of PI [Homo sapiens]
(precedingEvent)	[Reaction:1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Homo sapiens] [Reaction:1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] [Homo sapiens] [Reaction:1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Homo sapiens]
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