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Details on Person 2-acyl LPC is acylated to PC by LPCAT

Class:Id	Reaction:1482533
_displayName	2-acyl LPC is acylated to PC by LPCAT
_doRelease	TRUE
_timestamp	2012-05-31 09:40:34
authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524043] 2-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:975614] 2-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:1500578] acyl-CoA [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 [LiteratureReference:1482553] Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 [LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482541] Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production [LiteratureReference:1482640] Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells [LiteratureReference:1482581] A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase [LiteratureReference:429002] Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
modified	[InstanceEdit:1491767] Williams, MG, 2011-08-15 [InstanceEdit:1524048] Williams, MG, 2011-08-24 [InstanceEdit:1524171] Williams, MG, 2011-08-24 [InstanceEdit:1602347] Williams, MG, 2011-09-14 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2248822] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	2-acyl LPC is acylated to PC by LPCAT
output	[SimpleEntity:426925] PC [endoplasmic reticulum membrane] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C [Homo sapiens] [Reaction:1483219] PC is exchanged with PI by PITPNB [Homo sapiens] [Reaction:1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Homo sapiens] [Reaction:1482547] 1-acyl LPC is acylated to PC by LPCAT [Homo sapiens] [Reaction:1482533] 2-acyl LPC is acylated to PC by LPCAT [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294771] R-HSA-1482533.2
summation	[Summation:1482661] At the endoplasmic reticulum (ER) membrane, lysophospholipid...
(hasEvent)	[Pathway:1482788] Acyl chain remodelling of PC [Homo sapiens]
(precedingEvent)	[Reaction:1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] [Homo sapiens] [Reaction:1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C [Homo sapiens] [Reaction:1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] [Homo sapiens] [Reaction:1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] [Homo sapiens] [Reaction:1483142] PC is transphosphatidylated to PG by PLD1-4/6 [Homo sapiens] [Reaction:1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Homo sapiens] [Reaction:1483186] PC is converted to PS by PTDSS1 [Homo sapiens] [Reaction:8873923] STARD10 binds LPCAT1 and PC [Homo sapiens]
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