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Details on Person UniProt:P32189-3 GK
| Class:Id | ReferenceIsoform:148008 |
|---|---|
| _chainChangeLog | chain:1-559 added on Sat February 7 2015 |
| _displayName | UniProt:P32189-3 GK |
| _timestamp | 2025-02-21 19:59:26 |
| chain | chain:1-559 |
| checksum | 18268B7A4C6A09F3 |
| comment | FUNCTION Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis.CATALYTIC ACTIVITY glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)ACTIVITY REGULATION Potassium and magnesium-dependent.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.7.PATHWAY Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.INTERACTION Glycerol kinase activity is more cytosolic in some tissues. It probably represents the expression of isoforms lacking a transmembrane domain.SUBCELLULAR LOCATION In sperm and fetal tissues, the majority of the activity is associated with mitochondria.SUBCELLULAR LOCATION In adult tissues, such as liver the glycerol kinase activity is more cytosolic. It probably represents the expression of this isoform which lacks a transmembrane domain.ALTERNATIVE PRODUCTS Widely expressed in fetal and adult tissues.TISSUE SPECIFICITY Widely expressed in fetal and adult tissues.TISSUE SPECIFICITY The sole isoform expressed in adult liver and kidney.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the FGGY kinase family. |
| description | recommendedName: fullName evidence="17"Glycerol kinase shortName: Glycerokinase ecNumber evidence="6"2.7.1.30 alternativeName: fullName evidence="14"ATP:glycerol 3-phosphotransferase |
| geneName | GK |
| identifier | P32189 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Cytoplasm Disease variant Glycerol metabolism Kinase Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleotide-binding Nucleus Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988408] ENSEMBL:ENSG00000198814 GK [Homo sapiens] |
| secondaryIdentifier | GLPK_HUMAN A6NJP5 B2R833 Q6IQ27 Q8IVR5 Q9UMP0 Q9UMP1 |
| sequenceLength | 559 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P32189-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P32189-3 GK (148008)
