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Details on Person UniProt:O95210 STBD1
| Class:Id | ReferenceGeneProduct:147879 |
|---|---|
| _chainChangeLog | chain:1-358 added on Fri February 6 2015 |
| _displayName | UniProt:O95210 STBD1 |
| _timestamp | 2025-02-21 18:42:22 |
| chain | chain:1-358 |
| checksum | 9C98018B82B1578C |
| comment | FUNCTION Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.SUBUNIT Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (PubMed:20810658, PubMed:21893048). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (PubMed:24837458).INTERACTION Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048).TISSUE SPECIFICITY Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).DOMAIN The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.DOMAIN The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.PTM Ubiquitinated, which leads to proteasomal degradation. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="10"Starch-binding domain-containing protein 1 alternativeName: fullName evidence="10"Genethonin-1 alternativeName: fullName evidence="11"Glycophagy cargo receptor STBD1 |
| geneName | STBD1 GENX-3414 |
| identifier | O95210 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Autophagy Carbohydrate metabolism Cell membrane Endoplasmic reticulum Glycogen metabolism Membrane Phosphoprotein Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | STBD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996294] ENSEMBL:ENSG00000118804 STBD1 [Homo sapiens] |
| secondaryIdentifier | STBD1_HUMAN B3KVZ9 |
| sequenceLength | 358 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6801484] STBD1 [tertiary granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6801519] STBD1 [ficolin-1-rich granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6801561] STBD1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95210 STBD1 (147879)
