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Details on Person UniProt:O95843-2 GUCA1C
| Class:Id | ReferenceIsoform:147824 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-209 added on Sat February 7 2015;initiator methionine:1 for 147824 removed on Fri Nov 03 2023;initiator methionine: for 147824 added on Fri Nov 03 2023;initiator methionine: for 147824 removed on Fri Aug 15 2025;initiator methionine:1 for 147824 added on Fri Aug 15 2025 |
| _displayName | UniProt:O95843-2 GUCA1C |
| _timestamp | 2026-02-20 23:06:03 |
| chain | initiator methionine:1 chain:2-209 |
| checksum | A407E7D4AEBBAED3 |
| comment | FUNCTION Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.INTERACTION Retina.DOMAIN Binds three calcium ions (via EF-hand 2, 3 and 4). |
| description | recommendedName: Guanylyl cyclase-activating protein 3 shortName: GCAP 3 alternativeName: Guanylate cyclase activator 1C |
| geneName | GUCA1C GCAP3 |
| identifier | O95843 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Lipoprotein Metal-binding Myristate Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GUCA1C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997736] ENSEMBL:ENSG00000138472 GUCA1C [Homo sapiens] |
| secondaryIdentifier | GUC1C_HUMAN O95844 Q9UNM0 |
| sequenceLength | 209 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O95843-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95843-2 GUCA1C (147824)
