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Details on Person UniProt:Q9UQC2 GAB2
| Class:Id | ReferenceGeneProduct:147728 |
|---|---|
| _chainChangeLog | chain:1-676 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UQC2 GAB2 |
| _timestamp | 2024-11-03 20:14:31 |
| chain | chain:1-676 |
| checksum | 107623FD07D884C9 |
| comment | FUNCTION Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.SUBUNIT Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK.INTERACTION The SH3-binding motifs mediate interaction with SHC1 and GRB2.DOMAIN The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.PTM Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.PTM Dephosphorylated by PTPN11.SIMILARITY Belongs to the GAB family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: GRB2-associated-binding protein 2 alternativeName: GRB2-associated binder 2 alternativeName: Growth factor receptor bound protein 2-associated protein 2 alternativeName: pp100 |
| geneName | GAB2 KIAA0571 |
| identifier | Q9UQC2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytoplasm Membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GAB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995442] ENSEMBL:ENSG00000033327 GAB2 [Homo sapiens] |
| secondaryIdentifier | GAB2_HUMAN A2RRM2 A6NEW9 A7MD36 O60317 |
| sequenceLength | 676 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:230145] UniProt:Q9UQC2-2 GAB2 [Homo sapiens] [ReferenceIsoform:415619] UniProt:Q9UQC2-1 GAB2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:508239] GAB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:912529] p-Y-GAB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2685615] p-Y452,Y476,Y584-GAB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8855574] p-5Y-GAB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9677149] p-Y643-GAB2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:912530] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2685610] O4'-phospho-L-tyrosine at 452 [ModifiedResidue:2685619] O4'-phospho-L-tyrosine at 584 [ModifiedResidue:2685634] O4'-phospho-L-tyrosine at 476 [ModifiedResidue:8855566] O4'-phospho-L-tyrosine at 614 [ModifiedResidue:8855575] O4'-phospho-L-tyrosine at 643 |
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No pathways have been reviewed or authored by UniProt:Q9UQC2 GAB2 (147728)
