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Details on Person UniProt:Q13480 GAB1
| Class:Id | ReferenceGeneProduct:147726 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-694 added on Sat February 7 2015;initiator methionine:1 for 147726 removed on Fri Nov 03 2023;initiator methionine: for 147726 added on Fri Nov 03 2023;initiator methionine: for 147726 removed on Fri Aug 15 2025;initiator methionine:1 for 147726 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q13480 GAB1 |
| _timestamp | 2025-08-15 21:14:55 |
| chain | initiator methionine:1 chain:2-694 |
| checksum | E0FAC78772B6677B |
| comment | FUNCTION Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).SUBUNIT Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Within the complex interacts with METTL13 (PubMed:29408807). Interacts with GRB2 and with other SH2-containing proteins (PubMed:15010462). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with PTPRJ (PubMed:12475979). Interacts (phosphorylated) with PTPN11 (PubMed:15010462). Interacts with HCK (PubMed:15010462).INTERACTION Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GAB family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: GRB2-associated-binding protein 1 alternativeName: GRB2-associated binder 1 alternativeName: Growth factor receptor bound protein 2-associated protein 1 |
| geneName | GAB1 |
| identifier | Q13480 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Deafness Disease variant Non-syndromic deafness Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GAB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994819] ENSEMBL:ENSG00000109458 GAB1 [Homo sapiens] |
| secondaryIdentifier | GAB1_HUMAN A8K152 Q4W5G2 Q6P1W2 |
| sequenceLength | 694 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:230144] UniProt:Q13480-2 GAB1 [Homo sapiens] [ReferenceIsoform:405623] UniProt:Q13480-1 GAB1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:179795] GAB1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180344] p-5Y-GAB1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180496] p-Y627,Y659-GAB1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8855306] p-Y-GAB1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:180275] O4'-phospho-L-tyrosine at 659 [ModifiedResidue:180284] O4'-phospho-L-tyrosine at 627 [ModifiedResidue:180489] O4'-phospho-L-tyrosine at 447 [ModifiedResidue:180490] O4'-phospho-L-tyrosine at 472 [ModifiedResidue:180492] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:8855315] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q13480 GAB1 (147726)
