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Details on Person Carbonic anhydrase hydrates carbon dioxide (plasma membrane)

Class:Id	Reaction:1475025
_displayName	Carbonic anhydrase hydrates carbon dioxide (plasma membrane)
_doRelease	TRUE
_timestamp	2014-02-05 16:04:10
authored	[InstanceEdit:1475033] May, B, 2011-08-06
catalystActivity	[CatalystActivity:1475013] carbonate dehydratase activity of CA4,9,14,12:Zn2+ [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1475019] May, B, 2011-08-07
edited	[InstanceEdit:1475033] May, B, 2011-08-06
input	[SimpleEntity:1237009] CO2 [extracellular region] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:1237486] Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney [LiteratureReference:1237001] Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity [LiteratureReference:1237497] Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions [LiteratureReference:1237487] Catalysis and inhibition of human carbonic anhydrase IV [LiteratureReference:1243058] Structure and mechanism of carbonic anhydrase [LiteratureReference:1237524] Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes [LiteratureReference:1237457] Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines [LiteratureReference:1237461] Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies [LiteratureReference:1237503] Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides [LiteratureReference:1237485] Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers [LiteratureReference:1237509] The catalytic properties of human carbonic anhydrase IX
modified	[InstanceEdit:1973945] May, B, 2011-11-07 [InstanceEdit:2197779] May, B, 2012-04-14 [InstanceEdit:2252566] May, B, 2012-05-16 [InstanceEdit:5252140] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863268] Stephan, Ralf, 2024-02-28
name	Carbonic anhydrase hydrates carbon dioxide (plasma membrane)
output	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:425425] HCO3- [extracellular region]
precedingEvent	[Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens]
releaseDate	2012-06-12
reverseReaction	[Reaction:1475017] Carbonic anhydrase dehydrates bicarbonate (plasma membrane) [Homo sapiens] [Reaction:1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Homo sapiens]
reviewed	[InstanceEdit:2252565] Jassal, B, 2012-05-16 [InstanceEdit:2252567] Silverman, DN, 2012-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295210] R-HSA-1475025.3
summation	[Summation:1475023] Carbonic anhydrase IV (CA4, Zhu and Sly 1990, Okuyama et al....
(hasEvent)	[Pathway:1475029] Reversible hydration of carbon dioxide [Homo sapiens]
(reverseReaction)	[Reaction:1475017] Carbonic anhydrase dehydrates bicarbonate (plasma membrane) [Homo sapiens]
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