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Details on Person UniProt:Q9NP84-2 TNFRSF12A
| Class:Id | ReferenceIsoform:147402 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-129 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NP84-2 TNFRSF12A |
| _timestamp | 2024-11-03 19:54:24 |
| chain | signal peptide:1-27 chain:28-129 |
| checksum | BF3FDFB9C1E1C448 |
| comment | FUNCTION Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.SUBUNIT Associates with TRAF1 and TRAF2, and probably also with TRAF3.INTERACTION Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.INDUCTION By FGF1 and phorbol ester. |
| description | recommendedName: Tumor necrosis factor receptor superfamily member 12A alternativeName: Fibroblast growth factor-inducible immediate-early response protein 14 shortName: FGF-inducible 14 alternativeName: Tweak-receptor shortName: TweakR cdAntigenNameCD266/cdAntigenName |
| geneName | TNFRSF12A FN14 |
| identifier | Q9NP84 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Angiogenesis Apoptosis Cell adhesion Developmental protein Differentiation Disulfide bond Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNFRSF12A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999224] ENSEMBL:ENSG00000006327 TNFRSF12A [Homo sapiens] |
| secondaryIdentifier | TNR12_HUMAN D3DUA6 Q9HCS0 |
| sequenceLength | 129 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NP84-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NP84-2 TNFRSF12A (147402)
