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Details on Person MIB2 [cytosol]

Class:Id	EntityWithAccessionedSequence:1472879
_displayName	MIB2 [cytosol]
_timestamp	2023-11-01 17:19:20
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1472880] Orlic-Milacic, M, 2011-08-03
endCoordinate	955
modified	[InstanceEdit:9851876] D'Eustachio, Peter, 2023-11-01
name	MIB2 E3 ubiquitin-protein ligase MIB2 Mind bomb homolog 2
referenceEntity	[ReferenceGeneProduct:237347] UniProt:Q96AX9 MIB2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2159723] R-HSA-1472879.2
startCoordinate	1
(activeUnit)	[NegativeRegulation:9820383] Negative regulation by 'TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]' [CatalystActivity:9818825] ubiquitin-protein transferase activity of TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] [CatalystActivity:9818828] ubiquitin-protein transferase activity of CFLAR:MIB2:Ub:UBE2D1 [cytosol] [CatalystActivity:9818974] ubiquitin-protein transferase activity of MIB2:CYLD:UBE2D2 [cytosol]
(hasCandidate)	[CandidateSet:1911452] MIB [cytosol] [Homo sapiens] [CandidateSet:1911464] MIB/NEURL [cytosol] [Homo sapiens]
(hasComponent)	[Complex:9796354] TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] [Homo sapiens] [Complex:9796628] CFLAR:MIB2:Ub:UBE2D1 [cytosol] [Homo sapiens] [Complex:9816107] MIB2:CYLD:UBE2D2 [cytosol] [Homo sapiens] [Complex:9816109] TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:976075] E3 ligases in proteasomal degradation [cytosol] [Homo sapiens] [CandidateSet:8852046] RING-type E3 ubiquitin ligase [cytosol] [Homo sapiens]
(input)	[Reaction:9796342] MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [Homo sapiens] [Reaction:9796617] MIB2 binds CFLAR [Homo sapiens] [Reaction:9815510] MIB2 binds CYLD [Homo sapiens]
(output)	[BlackBoxEvent:9796626] MIB2 ubiquitinates CFLAR [Homo sapiens] [BlackBoxEvent:9815507] MIB2 ubiquitinates CYLD at K338, K530 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9906510] Update Tracker - [EntityWithAccessionedSequence:1472879] MIB2 [cytosol] - v87:[modifyEndCoordinate]
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No pathways have been reviewed or authored by MIB2 [cytosol] (1472879)