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Details on Person UniProt:P31995-3 FCGR2C
| Class:Id | ReferenceIsoform:147253 |
|---|---|
| _chainChangeLog | signal peptide:1-42 added on Fri February 6 2015;chain:43-323 added on Fri February 6 2015 |
| _displayName | UniProt:P31995-3 FCGR2C |
| _timestamp | 2026-02-20 22:21:27 |
| chain | signal peptide:1-42 chain:43-323 |
| checksum | DC4C1A22A0DE4572 |
| comment | FUNCTION Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.INTERACTION Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.DOMAIN Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.PTM Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.CAUTION Has sometimes been attributed to correspond to FcR-IIB.CAUTION FCGR2C is both a gene and a pseudogene in the human population, the reference genome corresponding currently to the non-functional allele with a stop codon at position 57. The sequence shown here with a Gln at that position is the one of the functional protein. |
| description | recommendedName: Low affinity immunoglobulin gamma Fc region receptor II-c shortName: IgG Fc receptor II-c alternativeName: CDw32 alternativeName: Fc-gamma RII-c shortName: Fc-gamma-RIIc shortName: FcRII-c cdAntigenNameCD32/cdAntigenName |
| geneName | FCGR2C CD32 FCG2 IGFR2 |
| identifier | P31995 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cytoplasm Disulfide bond Glycoprotein IgG-binding protein Immunoglobulin domain Membrane Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | FCGR2C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FCG2C_HUMAN O00523 O00524 O00525 |
| sequenceLength | 323 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P31995-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P31995-3 FCGR2C (147253)
