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Details on Person Alpha-defensins, theta-defensins and their synthetic analogu...
| Class:Id | Summation:1471316 |
|---|---|
| _displayName | Alpha-defensins, theta-defensins and their synthetic analogu... |
| _timestamp | 2011-11-04 10:57:38 |
| created | [InstanceEdit:1471368] Jupe, S, 2011-08-03 |
| literatureReference | [LiteratureReference:1966944] Defensins: natural anti-HIV peptides [LiteratureReference:1966959] Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4 [LiteratureReference:1471303] Activity of alpha- and theta-defensins against primary isolates of HIV-1 [LiteratureReference:1966953] Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms [LiteratureReference:1966956] Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro |
| modified | [InstanceEdit:1472846] Jupe, S, 2011-08-03 [InstanceEdit:1966952] Jupe, S, 2011-11-04 |
| text | Alpha-defensins, theta-defensins and their synthetic analogues the retrocyclins have been shown in numerous studies to have anti-HIV-1 activity (Chang & Klotman 2004). This appears to be mediated via multiple mechanisms including direct viral inactivation and down regulation of host-cell target co-receptors important for viral entry (Furci et al. 2007, Seidel et al. 2010). HNP1-3 act as lectins, binding with relatively high affinity to gp120 (KD range, 15.8-52.8 nM) on the HIV-1 envelope and CD4 (KD range, 8.0-34.9 nM) on host target cells, both important molecules for viral entry (Wang et al. 2004). Retrocyclins, artificial theta defensins predicted from human defensin pseudogenes, bind with even higher affinity whereas HNP-4 binding is much weaker (Wu et al. 2005). Alpha defensins have been demonstrated to inhibit the binding of gp120 to CD4 thus blocking HIV-1 fusion with its target cells (Furci et al. 2007). |
| (summation) | [Reaction:1471354] HNP1-3 bind gp120 [Homo sapiens] |
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