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Details on Person UniProt:Q9Y6I3 EPN1
| Class:Id | ReferenceGeneProduct:146962 |
|---|---|
| _chainChangeLog | chain:1-576 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Y6I3 EPN1 |
| _timestamp | 2026-02-20 22:43:01 |
| chain | chain:1-576 |
| checksum | 68DD433F3168E975 |
| comment | FUNCTION Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078).SUBUNIT Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1 (By similarity). Binds ubiquitinated proteins (By similarity). Binds AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2. Interacts with REPS2; the interaction is direct (PubMed:10393179, PubMed:10557078, PubMed:10764745). Interacts with EPS15; the interaction is direct (PubMed:10393179, PubMed:10764745). Interacts with ENTREP1 (PubMed:34927784).SUBCELLULAR LOCATION Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).ALTERNATIVE PRODUCTS The NPF repeat domain is involved in EPS15 binding.DOMAIN The DPW repeat domain is involved in AP2A2 and clathrin binding.DOMAIN The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1.PTM Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.PTM Ubiquitinated.MISCELLANEOUS May be due to a competing donor splice site.SIMILARITY Belongs to the epsin family.SEQUENCE CAUTION The bubble's bend - Issue 42 of January 2004 |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Epsin-1 alternativeName: EH domain-binding mitotic phosphoprotein alternativeName: EPS-15-interacting protein 1 |
| geneName | EPN1 |
| identifier | Q9Y6I3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Coated pit Cytoplasm Endocytosis Lipid-binding Membrane Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | EPN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001746] ENSEMBL:ENSG00000063245 EPN1 [Homo sapiens] |
| secondaryIdentifier | EPN1_HUMAN Q86ST3 Q9HA18 |
| sequenceLength | 576 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:146963] UniProt:Q9Y6I3-2 EPN1 [Homo sapiens] [ReferenceIsoform:146964] UniProt:Q9Y6I3-3 EPN1 [Homo sapiens] [ReferenceIsoform:416124] UniProt:Q9Y6I3-1 EPN1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:182952] EPN1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8865826] EPN1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y6I3 EPN1 (146962)
