Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9NXG6-3 P4HTM
| Class:Id | ReferenceIsoform:146802 |
|---|---|
| _chainChangeLog | chain:1-502 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NXG6-3 P4HTM |
| _timestamp | 2026-02-20 23:09:00 |
| chain | chain:1-502 |
| checksum | A2DAE4ACF4A2E18C |
| comment | FUNCTION Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.CATALYTIC ACTIVITY L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2COFACTOR Binds 1 Fe(2+) ion per subunit.COFACTOR Homodimer.INTERACTION Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.INDUCTION By hypoxia in many cultured cell lines.PTM Glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Intron retention.SEQUENCE CAUTION Intron retention. |
| description | recommendedName: Transmembrane prolyl 4-hydroxylase shortName: P4H-TM ecNumber evidence="7"1.14.11.29 alternativeName: Hypoxia-inducible factor prolyl hydroxylase 4 shortName: HIF-PH4 shortName: HIF-prolyl hydroxylase 4 shortName: HPH-4 |
| geneName | P4HTM PH4 |
| identifier | Q9NXG6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Dioxygenase Disease variant Endoplasmic reticulum Epilepsy Glycoprotein Intellectual disability Iron Membrane Metal-binding Oxidoreductase Proteomics identification Reference proteome Repeat Signal-anchor Transmembrane Transmembrane helix Vitamin C |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | P4HTM |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962279] ENSEMBL:ENSG00000178467 P4HTM [Homo sapiens] |
| secondaryIdentifier | P4HTM_HUMAN Q6PAG6 Q8TCJ9 Q8WV55 Q96F22 Q9BW77 |
| sequenceLength | 502 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9NXG6-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NXG6-3 P4HTM (146802)
