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Details on Person Rhodopsin (RHO) is localised to both the disc membrane and t...
| Class:Id | Summation:1467447 |
|---|---|
| _displayName | Rhodopsin (RHO) is localised to both the disc membrane and t... |
| _timestamp | 2012-10-02 12:42:31 |
| created | [InstanceEdit:1467435] Jassal, Bijay, 2011-08-01 |
| modified | [InstanceEdit:1472887] Jassal, Bijay, 2011-08-04 [InstanceEdit:2464815] Jassal, Bijay, 2012-09-03 [InstanceEdit:2466077] Jassal, Bijay, 2012-09-06 [InstanceEdit:2473461] Jassal, Bijay, 2012-09-24 [InstanceEdit:2500293] Jassal, B, 2012-10-02 |
| text | Rhodopsin (RHO) is localised to both the disc membrane and the plasma membrane of rod outer segments (ROS). All-trans-retinal (atRAL) released from rhodopsin during the bleaching process, needs to translocate to the cytosol for reduction to all-trans-retinol (atROL) via all-trans-retinol dehydrogenases. Although atRAL can diffuse through membranes unaided, there exists an ABC transporter on disc membranes which may facilitate the transport of excess atRAL. Retinal-specific ATP-binding cassette transporter (ABCA4, ABCR) is the only ABC transporter which mediates the transport of retinoids (Biswas & Biswas 2000). Studies using bovine ABCA4 demonstrates atRAL transport (Sun et al. 1999). Human ABCR was found to be identical to the ABC transporter linked to Stargardt's disease type 1 (STGD1, MIM:248200), a cause of macular degeneration in childhood (Nasonkin et al. 1998). |
| (summation) | [Reaction:1467466] ABCA4 mediates atRAL transport [Homo sapiens] |
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No pathways have been reviewed or authored by Rhodopsin (RHO) is localised to both the disc membrane and t... (1467447)
