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Details on Person UniProt:O95977 S1PR4
| Class:Id | ReferenceGeneProduct:146743 |
|---|---|
| _chainChangeLog | chain:1-384 added on Sat February 7 2015 |
| _displayName | UniProt:O95977 S1PR4 |
| _timestamp | 2026-02-20 22:59:47 |
| chain | chain:1-384 |
| checksum | 369A7BC56AB46A47 |
| comment | FUNCTION G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway (By similarity). Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response (By similarity). In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response (By similarity).SUBUNIT Interacts with FPR2.INTERACTION Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Sphingosine 1-phosphate receptor 4 shortName: S1P receptor 4 shortName: S1P4 alternativeName: Endothelial differentiation G-protein coupled receptor 6 alternativeName: Sphingosine 1-phosphate receptor Edg-6 shortName: S1P receptor Edg-6 |
| geneName | S1PR4 EDG6 |
| identifier | O95977 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | S1PR4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997421] ENSEMBL:ENSG00000125910 S1PR4 [Homo sapiens] |
| secondaryIdentifier | S1PR4_HUMAN D6W612 |
| sequenceLength | 384 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:419347] S1PR4 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95977 S1PR4 (146743)
