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Details on Person In S. aureus, rather than cause gross membrane changes, HNP-...
| Class:Id | Summation:1467195 |
|---|---|
| _displayName | In S. aureus, rather than cause gross membrane changes, HNP-... |
| _timestamp | 2011-11-07 11:23:01 |
| created | [InstanceEdit:1467229] Jupe, S, 2011-07-29 |
| literatureReference | [LiteratureReference:1973969] Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II [LiteratureReference:1973963] Lipid II as a target for antibiotics |
| modified | [InstanceEdit:1973019] Jupe, S, 2011-11-04 [InstanceEdit:1973962] Jupe, S, 2011-11-07 |
| text | In S. aureus, rather than cause gross membrane changes, HNP-1 (de Leeuw et al. 2010) and hBD3 (Sass et al. 2011) appear to interfere with cell wall biosynthetic pathways by binding to Lipid II (undecaprenylpyrophosphate-MurNAc[pentapeptide]-GlcNAc), an essential precursor of bacterial cell walls and the target of several antibiotics (Breukink & de Krujiff 2007). The transformation of monomeric lipid II into a polymeric peptidoglycan by the bifunctional S. aureus enzyme Penicillin-binding protein 2 (PBP2) is inhibited by hBD3 (Sass et al. 2011) resulting in local lesions of the cell wall layer through which membranes and cytoplasmic contents ultimately protrude. |
| (summation) | [Reaction:1467209] Binding of defensins to lipid II [Homo sapiens] |
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No pathways have been reviewed or authored by In S. aureus, rather than cause gross membrane changes, HNP-... (1467195)
