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Details on Person UniProt:Q8N1I0-4 DOCK4
| Class:Id | ReferenceIsoform:146497 |
|---|---|
| _chainChangeLog | chain:1-1966 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N1I0-4 DOCK4 |
| _timestamp | 2024-11-03 19:45:29 |
| chain | chain:1-1966 |
| checksum | 9CFB6299F7730AA9 |
| comment | FUNCTION Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435).FUNCTION Has a higher guanine nucleotide exchange factor activity compared to other isoforms.SUBUNIT Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1 (PubMed:12628187). Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1 (PubMed:16464467). Interacts with the SH3 domain of CRK (PubMed:12628187). Interacts with FASLG (PubMed:19807924). Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435). Interacts with USH1C (via PDZ 1 domain) (PubMed:16464467).INTERACTION Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells.ALTERNATIVE PRODUCTS Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.TISSUE SPECIFICITY May be specifically expressed in the brain and eye.DOMAIN The DOCKER domain mediates interaction with small GTPases like RAC1 and is required for their activation.SIMILARITY Belongs to the DOCK family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Dedicator of cytokinesis protein 4 |
| geneName | DOCK4 KIAA0716 |
| identifier | Q8N1I0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Cell projection Cytoplasm Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Proto-oncogene Reference proteome SH3 domain SH3-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DOCK4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000015] ENSEMBL:ENSG00000128512 DOCK4 [Homo sapiens] |
| secondaryIdentifier | DOCK4_HUMAN O14584 O94824 Q8NB45 |
| sequenceLength | 1966 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8N1I0-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8N1I0-4 DOCK4 (146497)
