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Details on Person UniProt:O76075-3 DFFB
| Class:Id | ReferenceIsoform:146313 |
|---|---|
| _chainChangeLog | chain:1-338 added on Fri February 6 2015 |
| _displayName | UniProt:O76075-3 DFFB |
| _timestamp | 2024-11-03 19:45:24 |
| chain | chain:1-338 |
| checksum | 0B0F3F8D91209389 |
| comment | FUNCTION Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.ACTIVITY REGULATION Inhibited by DFFA (DFF45).SUBUNIT Heterodimer of DFFA and DFFB (PubMed:11371636). Interacts with H1-1 (PubMed:19882353).INTERACTION May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
| description | recommendedName: DNA fragmentation factor subunit beta ecNumber: 3.-.-.- alternativeName: Caspase-activated deoxyribonuclease shortName: CAD shortName: Caspase-activated DNase alternativeName: Caspase-activated nuclease shortName: CPAN alternativeName: DNA fragmentation factor 40 kDa subunit shortName: DFF-40 |
| geneName | DFFB CAD DFF2 DFF40 |
| identifier | O76075 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytoplasm Hydrolase Nuclease Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DFFB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994176] ENSEMBL:ENSG00000169598 DFFB [Homo sapiens] |
| secondaryIdentifier | DFFB_HUMAN O60521 Q5SR22 Q9BYI4 Q9BYI5 Q9BYI6 |
| sequenceLength | 338 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O76075-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O76075-3 DFFB (146313)
