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Details on Person UniProt:Q9GZP9 DERL2
| Class:Id | ReferenceGeneProduct:146299 |
|---|---|
| _chainChangeLog | chain:1-239 added on Sat February 7 2015 |
| _displayName | UniProt:Q9GZP9 DERL2 |
| _timestamp | 2024-11-03 20:14:01 |
| chain | chain:1-239 |
| checksum | CAA228487C3CCB5C |
| comment | FUNCTION Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).FUNCTION (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses.SUBUNIT Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (PubMed:16186509). Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:16186509). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (PubMed:16449189). Interacts with OS9 (PubMed:19084021). Interacts with SELENOK and SELENOS (PubMed:22016385). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (PubMed:26565908). Interacts with CCDC47 (By similarity).INTERACTION Ubiquitous. Overexpressed in various hepatocarcinomas.INDUCTION Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).SIMILARITY Belongs to the derlin family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="12"Derlin-2 alternativeName: Degradation in endoplasmic reticulum protein 2 shortName: DERtrin-2 alternativeName: fullName evidence="12"Der1-like protein 2 alternativeName: fullName evidence="17"F-LAN-1 alternativeName: fullName evidence="11"F-LANa |
| geneName | DERL2 DER2 FLANA CGI-101 SBBI53 |
| identifier | Q9GZP9 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Host-virus interaction Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix Unfolded protein response |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DERL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002304] ENSEMBL:ENSG00000072849 DERL2 [Homo sapiens] |
| secondaryIdentifier | DERL2_HUMAN Q9Y3A7 |
| sequenceLength | 239 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5362350] DERL2 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9GZP9 DERL2 (146299)
