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Details on Person UniProt:Q9BUN8 DERL1
| Class:Id | ReferenceGeneProduct:146296 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-251 added on Fri February 6 2015;initiator methionine:1 for 146296 removed on Fri Nov 03 2023;initiator methionine: for 146296 added on Fri Nov 03 2023;initiator methionine: for 146296 removed on Fri Aug 15 2025;initiator methionine:1 for 146296 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BUN8 DERL1 |
| _timestamp | 2025-08-15 22:07:23 |
| chain | initiator methionine:1 chain:2-251 |
| checksum | 4A6E0DB68D9AF244 |
| comment | FUNCTION Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (PubMed:15215856, PubMed:33658201). Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane (PubMed:33658201). This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:33658201). The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first (PubMed:33658201). May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).FUNCTION (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.SUBUNIT Homotetramer (PubMed:33658201). The four subunits of the tetramer are arranged in a twofold symmetry (PubMed:33658201). Forms heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts (via SHP-box motif) with VCP (PubMed:16186509, PubMed:16186510, PubMed:16289116, PubMed:16449189, PubMed:27714797). Interacts with AMFR, SELENOS, SEL1L, SELENOK and SYVN1, as well as with SEL1L-SYVN1 and VCP-SELENOS protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with NGLY1 and YOD1. Does not bind to EDEM1. Interacts with DNAJB9. Interacts with RNF103 (PubMed:15215856, PubMed:16055502, PubMed:16186509, PubMed:16186510, PubMed:16289116, PubMed:16449189, PubMed:18675248, PubMed:19818707, PubMed:22016385). Interacts with HM13 (PubMed:25239945). Interacts with XBP1 isoform 1 (via luminal/ectodomain domain); the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage (PubMed:25239945). Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (PubMed:26565908). May interact with UBXN6 (PubMed:19275885). Interacts with ZFAND2B; probably through VCP (PubMed:24160817). Interacts with CCDC47 (By similarity). Interacts with C18orf32 (PubMed:29275994). May interact with TRAM1 (PubMed:19121997). Forms a complex with SVIP and VCP/p97 (PubMed:17872946).SUBUNIT (Microbial infection) Interacts with the cytomegalovirus US11 protein.INTERACTION Ubiquitous.SIMILARITY Belongs to the derlin family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="24"Derlin-1 alternativeName: Degradation in endoplasmic reticulum protein 1 shortName: DERtrin-1 alternativeName: fullName evidence="24"Der1-like protein 1 |
| geneName | DERL1 DER1 UNQ243/PRO276 |
| identifier | Q9BUN8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Endoplasmic reticulum Host-virus interaction Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Unfolded protein response |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DERL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992402] ENSEMBL:ENSG00000136986 DERL1 [Homo sapiens] |
| secondaryIdentifier | DERL1_HUMAN B3KW41 E9PH19 |
| sequenceLength | 251 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965128] UniProt:Q9BUN8-1 DERL1 [Homo sapiens] [ReferenceIsoform:8965129] UniProt:Q9BUN8-2 DERL1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6781898] DERL1 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BUN8 DERL1 (146296)
