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Details on Person HNP1-4 are released into phagocytic vacuoles

Class:Id	Reaction:1462041
_displayName	HNP1-4 are released into phagocytic vacuoles
_doRelease	TRUE
_timestamp	2011-11-23 11:08:12
authored	[InstanceEdit:1254178] Jupe, S, 2011-04-28
compartment	[Compartment:1470028] azurophil granule lumen [Compartment:984] extracellular region
created	[InstanceEdit:1461974] Jupe, S, 2011-07-27
edited	[InstanceEdit:1461956] Jupe, S, 2011-07-27
input	[CandidateSet:1470049] Defensins alpha 1-4 [azurophil granule lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1472823] Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines [LiteratureReference:1472841] Defensins: endogenous antibiotic peptides from human leukocytes [LiteratureReference:1472835] Processing and targeting of granule proteins in human neutrophils
modified	[InstanceEdit:1471368] Jupe, S, 2011-08-03 [InstanceEdit:1472846] Jupe, S, 2011-08-03 [InstanceEdit:1966964] Jupe, S, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HNP1-4 are released into phagocytic vacuoles
output	[CandidateSet:1471313] Defensins alpha 1-4 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:1462003] HNP1-4 are stored in primary neutrophil granules [Homo sapiens] [Reaction:1462039] Pro-HNP1-4 are cleaved to biologically active defensin [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1966942] McDermott, AM, 2011-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016254] R-HSA-1462041.2
summation	[Summation:1472838] Human neutrophils contain thousands of cytoplasmic granules....
(hasEvent)	[Pathway:1462054] Alpha-defensins [Homo sapiens]
(precedingEvent)	[Reaction:1462014] Alpha-defensins form biologically active dimers [Homo sapiens] [Reaction:1471314] HNP1-3 bind CD4 [Homo sapiens] [Reaction:1471354] HNP1-3 bind gp120 [Homo sapiens] [Reaction:1972385] ADP-Ribosylation of HNP-1 [Homo sapiens]
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No pathways have been reviewed or authored by HNP1-4 are released into phagocytic vacuoles (1462041)