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Details on Person pro-HD5 is cleaved by trypsin

Class:Id	Reaction:1461993
_displayName	pro-HD5 is cleaved by trypsin
_doRelease	TRUE
_timestamp	2011-11-23 11:17:42
authored	[InstanceEdit:1254178] Jupe, S, 2011-04-28
catalystActivity	[CatalystActivity:1462008] serine-type peptidase activity of Trypsin 2, 3 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1461974] Jupe, S, 2011-07-27
edited	[InstanceEdit:1461956] Jupe, S, 2011-07-27
input	[EntityWithAccessionedSequence:1471344] DEFA5(20-94) [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1462011] Paneth cell trypsin is the processing enzyme for human defensin-5
modified	[InstanceEdit:1471368] Jupe, S, 2011-08-03 [InstanceEdit:1472846] Jupe, S, 2011-08-03 [InstanceEdit:1966999] Jupe, S, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pro-HD5 is cleaved by trypsin
output	[EntityWithAccessionedSequence:1462017] DEFA5(?-94) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:1462005] pro-defensin alpha 5 is secreted [Homo sapiens] [Reaction:1461995] pro-defensin alpha 5 is stored in Paneth cell granules [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1966942] McDermott, AM, 2011-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016728] R-HSA-1461993.2
summation	[Summation:1461984] Pro HD5 is stored and secreted from granules of Paneth cells...
(hasEvent)	[Pathway:1462054] Alpha-defensins [Homo sapiens]
(precedingEvent)	[Reaction:1462014] Alpha-defensins form biologically active dimers [Homo sapiens]
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No pathways have been reviewed or authored by pro-HD5 is cleaved by trypsin (1461993)