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Details on Person Pro HD5 is stored and secreted from granules of Paneth cells...
| Class:Id | Summation:1461984 |
|---|---|
| _displayName | Pro HD5 is stored and secreted from granules of Paneth cells... |
| _timestamp | 2011-11-04 11:03:36 |
| created | [InstanceEdit:1461974] Jupe, S, 2011-07-27 |
| literatureReference | [LiteratureReference:1462040] Localization of human intestinal defensin 5 in Paneth cell granules [LiteratureReference:1462024] Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease [LiteratureReference:1462011] Paneth cell trypsin is the processing enzyme for human defensin-5 [LiteratureReference:1966976] Paneth cell ?-defensins in enteric innate immunity |
| modified | [InstanceEdit:1966964] Jupe, S, 2011-11-04 |
| text | Pro HD5 is stored and secreted from granules of Paneth cells in the small intestine (Porter et al. 1997, Cunliffe et al. 2001). The serine protease tryspin colocalizes to these granules as the inactive zymogen trypsinogen. Removal of the defensin propiece occurs extracellularly after release in to the crypt lumen, and is mediated by trypsin 2 (anionic trypsin) and/or trypsin-3 (mesotrypsin) which are converted to their active forms by enteroprotease like enzymes or by autoactivation (Ghosh et al. 2002, Ouelette 2011). |
| (summation) | [Reaction:1461993] pro-HD5 is cleaved by trypsin [Homo sapiens] |
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No pathways have been reviewed or authored by Pro HD5 is stored and secreted from granules of Paneth cells... (1461984)
