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Details on Person Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids

Class:Id	Reaction:1461971
_displayName	Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
_doRelease	TRUE
_timestamp	2016-09-23 21:43:58
authored	[InstanceEdit:1254178] Jupe, S, 2011-04-28
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1461974] Jupe, S, 2011-07-27
edited	[InstanceEdit:1461956] Jupe, S, 2011-07-27
entityOnOtherCell	[SimpleEntity:1462049] Anionic phospholipids [plasma membrane]
input	[SimpleEntity:1462049] Anionic phospholipids [plasma membrane] [DefinedSet:1471331] Alpha-defensin dimers [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1462025] Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity [LiteratureReference:1461964] Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores [LiteratureReference:1467275] Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue
modified	[InstanceEdit:1467229] Jupe, S, 2011-07-29 [InstanceEdit:1471368] Jupe, S, 2011-08-03 [InstanceEdit:1471381] Jupe, S, 2011-08-03 [InstanceEdit:1966952] Jupe, S, 2011-11-04 [InstanceEdit:8940239] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
output	[Complex:1471345] Alpha-defensin dimers:anionic phospholipids [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1462014] Alpha-defensins form biologically active dimers [Homo sapiens] [Reaction:1462041] HNP1-4 are released into phagocytic vacuoles [Homo sapiens] [Reaction:1461993] pro-HD5 is cleaved by trypsin [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1966942] McDermott, AM, 2011-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016119] R-HSA-1461971.3
summation	[Summation:1461962] The alpha-defensin dimers adsorb onto microbial membrane ani...
(hasEvent)	[Pathway:1462054] Alpha-defensins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1461982] Alpha-defensin dimers multimerize to form a pore complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782235] Update Tracker - [Reaction:1461971] Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids - v59:[add_removeLiteratureReference]
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No pathways have been reviewed or authored by Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (1461971)