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Details on Person UniProt:Q8WY07 SLC7A3
| Class:Id | ReferenceGeneProduct:146083 |
|---|---|
| _chainChangeLog | chain:1-619 added on Sat February 7 2015 |
| _displayName | UniProt:Q8WY07 SLC7A3 |
| _timestamp | 2024-11-03 19:35:52 |
| chain | chain:1-619 |
| checksum | 211254FA87D43978 |
| comment | FUNCTION Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158).CATALYTIC ACTIVITY L-arginine(in) = L-arginine(out)CATALYTIC ACTIVITY L-lysine(in) = L-lysine(out)CATALYTIC ACTIVITY L-ornithine(in) = L-ornithine(out)INTERACTION Highly expressed in thymus, uterus and testis (PubMed:11591158). Detected at lower levels in brain, mammary gland, prostate, salivary gland and fetal spleen (PubMed:11591158). In brain, highest expression in thalamus, hippocampus and amygdala (PubMed:11591158).PTM N-glycosylated.SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: fullName evidence="5"Cationic amino acid transporter 3 shortName: CAT-3 shortName: CAT3 alternativeName: Cationic amino acid transporter y+ alternativeName: Solute carrier family 7 member 3 |
| geneName | SLC7A3 ATRC3 CAT3 |
| identifier | Q8WY07 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid transport Cell membrane Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SLC7A3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998247] ENSEMBL:ENSG00000165349 SLC7A3 [Homo sapiens] |
| secondaryIdentifier | CTR3_HUMAN D3DVU7 Q5JQR2 Q8N185 Q8NCA7 Q96SZ7 |
| sequenceLength | 619 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:375779] SLC7A3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8WY07 SLC7A3 (146083)
