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Details on Person Ikonomov, OC
| Class:Id | Person:1460259 |
| _displayName | Ikonomov, OC |
| _timestamp | 2011-07-26 01:36:58 |
| created | [InstanceEdit:1460249] May, B, 2011-07-26 |
| initial | OC |
| surname | Ikonomov |
| (author) | [LiteratureReference:1460248] The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice [LiteratureReference:1460254] PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis [LiteratureReference:1460267] Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes [LiteratureReference:1460268] Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity [LiteratureReference:1460276] ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality [LiteratureReference:1460290] Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells [LiteratureReference:1460299] Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation [LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1675829] Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion [LiteratureReference:1675955] PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin |
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No pathways have been reviewed or authored by Ikonomov, OC (1460259)