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Details on Person UniProt:O75462 CRLF1
| Class:Id | ReferenceGeneProduct:145944 |
|---|---|
| _chainChangeLog | signal peptide:1-37 added on Sat February 7 2015;chain:38-422 added on Sat February 7 2015 |
| _displayName | UniProt:O75462 CRLF1 |
| _timestamp | 2024-11-03 19:35:49 |
| chain | signal peptide:1-37 chain:38-422 |
| checksum | AD9DEFCB01B84228 |
| comment | FUNCTION In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.SUBUNIT Forms covalent di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine CLCF1/CLC; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR (PubMed:26858303, PubMed:9686600). The CRLF1-CLCF1 heterodimer binds SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety (PubMed:26858303). The tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1 (PubMed:26858303).INTERACTION Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.INDUCTION Up-regulated in fibroblast primary cell cultures under stimulation by IFNG/IFN-gamma, TNF and IL6/interleukin-6.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the type I cytokine receptor family. Type 3 subfamily. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Cytokine receptor-like factor 1 alternativeName: Cytokine-like factor 1 shortName: CLF-1 alternativeName: ZcytoR5 |
| geneName | CRLF1 UNQ288/PRO327 |
| identifier | O75462 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CRLF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997654] ENSEMBL:ENSG00000006016 CRLF1 [Homo sapiens] |
| secondaryIdentifier | CRLF1_HUMAN Q9UHH5 |
| sequenceLength | 422 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5693174] CRLF1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8950296] CRLF1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75462 CRLF1 (145944)
