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Details on Person RALA hydrolyzes GTP

Class:Id	Reaction:1458485
_displayName	RALA hydrolyzes GTP
_doRelease	TRUE
_timestamp	2014-02-05 23:08:46
authored	[InstanceEdit:1454729] May, B, 2011-07-17
catalystActivity	[CatalystActivity:1458493] GTPase activity of GGC-RALA:GTP [cytoplasmic vesicle membrane]
compartment	[Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:1458495] May, B, 2011-07-21
edited	[InstanceEdit:1454729] May, B, 2011-07-17
inferredFrom	[Reaction:1458501] RalA Hydrolyzes GTP [Mus musculus]
input	[Complex:1458506] GGC-RALA:GTP [cytoplasmic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1458655] Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein
modified	[InstanceEdit:1458530] May, B, 2011-07-21 [InstanceEdit:1458654] May, B, 2011-07-21 [InstanceEdit:1857876] D'Eustachio, P, 2011-10-29 [InstanceEdit:1977302] May, B, 2011-11-08 [InstanceEdit:2010555] May, B, 2011-11-22 [InstanceEdit:2108991] May, B, 2012-02-12 [InstanceEdit:2143453] May, B, 2012-02-26 [InstanceEdit:2255340] May, B, 2012-05-19 [InstanceEdit:2263482] May, B, 2012-05-21 [InstanceEdit:2428915] May, B, 2012-08-08 [InstanceEdit:2454134] May, B, 2012-08-21 [InstanceEdit:5252546] May, B, 2014-02-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RALA hydrolyzes GTP
output	[Complex:1458466] GGC-RALA:GDP [cytoplasmic vesicle membrane] [Homo sapiens] [SimpleEntity:2255331] Pi [cytoplasmic vesicle membrane]
precedingEvent	[Reaction:2255342] RALA exchanges GDP for GTP [Homo sapiens] [Reaction:1458485] RALA hydrolyzes GTP [Homo sapiens] [Reaction:1458463] p-AKT2 phosphorylates RGC2 [Homo sapiens]
regulatedBy	[PositiveRegulation:1458520] Positive regulation by 'RGC1:RGC2 [cytosol]'
regulationReference	[RegulationReference:9642262] Positive regulation by 'RGC1:RGC2 [cytosol]' A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
releaseDate	2012-09-18
reviewed	[InstanceEdit:2454132] Klip, Amira, 2012-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464854] R-HSA-1458485.5
summation	[Summation:1458662] RALA is a guanine nucleotide binding protein that hydrolyzes... [Summation:1458562] As inferred from mouse, RGC1:RGC2 (RALGAPB:RALGAPA2) activat...
(hasEvent)	[Pathway:1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:2255342] RALA exchanges GDP for GTP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775505] Update Tracker - [Reaction:1458485] RALA hydrolyzes GTP - v78:[addSummation]
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