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Details on Person UniProt:Q8BT14-3 Cnot4
| Class:Id | ReferenceIsoform:145786 |
|---|---|
| _chainChangeLog | chain:1-575 added on Fri February 6 2015 |
| _displayName | UniProt:Q8BT14-3 Cnot4 |
| _timestamp | 2023-11-03 16:19:35 |
| chain | chain:1-575 |
| checksum | E0B763C8262D03CA |
| comment | FUNCTION Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Interacts (via RING domain) with UBE2D2. Interacts with ABCE1, PINK1 and PELO.SUBCELLULAR LOCATION Autoubiquitinated. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: CCR4-NOT transcription complex subunit 4 ecNumber evidence="1"2.3.2.27 alternativeName: CCR4-associated factor 4 alternativeName: E3 ubiquitin-protein ligase CNOT4 alternativeName: Potential transcriptional repressor NOT4Hp alternativeName: fullName evidence="9"RING-type E3 ubiquitin transferase CNOT4 |
| geneName | Cnot4 Not4 |
| identifier | Q8BT14 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Coiled coil Cytoplasm Metal-binding Methylation Nucleus Phosphoprotein Reference proteome RNA-binding Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cnot4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CNOT4_MOUSE Q8CCR4 Q9CV74 Q9Z1D0 |
| sequenceLength | 575 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q8BT14-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8BT14-3 Cnot4 (145786)
