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Details on Person MT-MMPs are regulated by targetting to specific domains of t...

Class:IdSummation:1454779
_displayNameMT-MMPs are regulated by targetting to specific domains of t...
_timestamp2011-07-18 14:06:33
created[InstanceEdit:1454796] Jupe, S, 2011-07-18
literatureReference[LiteratureReference:1454863] Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion
[LiteratureReference:1454784] Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains
[LiteratureReference:1454828] Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis
[LiteratureReference:1454766] Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity
modified[InstanceEdit:1454885] Jupe, S, 2011-07-18
textMT-MMPs are regulated by targetting to specific domains of the cell membrane such as invadopodia (Nakahara et al. 1997) and caveolae (Annabi et al. 2001). Cycling between the cell surface and intracellular pools occurs via clathrin-coated pits (Jiang et al. 2001, Uekita et al. 2001). The cytoplasmic tail of MT-MMPs is known to have a role in membrane doamin targetting.
(summation)[Reaction:1454810] MTMMPs are targetted to specific cell membrane domains [Homo sapiens]
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