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Details on Person Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13

Class:Id	BlackBoxEvent:1454757
_displayName	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
_doRelease	TRUE
_timestamp	2024-11-25 14:36:12
authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:2537494] metalloendopeptidase activity of MMP1-3, 7-9, 12, 13 [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1454796] Jupe, S, 2011-07-18
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
input	[DefinedSet:2537527] Cleaved collagen fibrils [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2537480] H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen [LiteratureReference:1602465] SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [LiteratureReference:2537496] Calprotectin inhibits matrix metalloproteinases by sequestration of zinc [LiteratureReference:2537473] Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins [LiteratureReference:1564149] Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein [LiteratureReference:2537508] Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain [LiteratureReference:2537525] Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain [LiteratureReference:2537513] Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts [LiteratureReference:2537521] Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme [LiteratureReference:2537509] Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP, and human MMP19 have a conserved unique cysteine in the catalytic domain
modified	[InstanceEdit:1454885] Jupe, S, 2011-07-18 [InstanceEdit:1638827] Jupe, S, 2011-10-10 [InstanceEdit:2142923] Jupe, S, 2012-02-24 [InstanceEdit:2225573] Jupe, S, 2012-05-04 [InstanceEdit:2537528] Jupe, S, 2012-10-29 [InstanceEdit:2550422] Jupe, S, 2012-11-02 [InstanceEdit:2580335] Jupe, S, 2012-11-12 [InstanceEdit:2580336] Jupe, S, 2012-11-12 [InstanceEdit:6793414] Jupe, Steve, 2015-09-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929403] D'Eustachio, Peter, 2024-11-25
name	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
precedingEvent	[Reaction:1454822] Collagen type I degradation by MMP1,2,8,13, PRSS2 [Homo sapiens] [Reaction:1458433] Collagen type I degradation by MMP14 [Homo sapiens] [Reaction:2473596] Collagen type I degradation by MMP15 [Homo sapiens] [Reaction:1474197] Collagen type II degradation by MMP1,3,8,13,PRSS2 [Homo sapiens] [Reaction:1474196] Collagen type II degradation by MMP14 [Homo sapiens] [Reaction:1474213] Collagen type III degradation by MMP1,8,9,13 [Homo sapiens] [Reaction:2485111] Collagen type III degradation by MMP10 [Homo sapiens] [Reaction:1474210] Collagen type III degradation by MMP14 [Homo sapiens] [Reaction:1564142] Collagen type IV degradation by MMP2,3,4,9,10,12 [Homo sapiens] [Reaction:1564164] Collagen type V degradation by MMP2,9,10 [Homo sapiens] [Reaction:1564112] Collagen type VI degradation by MMP2,9,11 [Homo sapiens] [Reaction:1564120] Collagen type VII degradation by MMP1,2,3 [Homo sapiens] [Reaction:2482180] Collagen type VIII degradation by ELANE [Homo sapiens] [Reaction:1564169] Collagen type VIII degradation by MMP1 [Homo sapiens] [Reaction:1564184] Collagen type IX degradation by MMP3,13 [Homo sapiens] [Reaction:1564143] Collagen type X degradation by MMP1,2 [Homo sapiens] [Reaction:2484882] Collagen type X degradation by MMP3, 13 [Homo sapiens] [Reaction:1564179] Collagen type XI degradation by MMP1,2,3,9 [Homo sapiens] [Reaction:2168046] Collagen type XII degradation by MMP12 [Homo sapiens] [Reaction:1564117] Collagen type XIV degradation by MMP9,13 [Homo sapiens] [Reaction:2168982] Collagen type XVI degradation by MMP9 [Homo sapiens] [BlackBoxEvent:2473594] Collagen type II degradation by MMP15 [Homo sapiens] [BlackBoxEvent:2473584] Collagen type III degradation by MMP15 [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200323] R-HSA-1454757.4
summation	[Summation:1454743] Gelatin is formed when collagen becomes partly or completely...
(hasEvent)	[Pathway:1442490] Collagen degradation [Homo sapiens]
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No pathways have been reviewed or authored by Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (1454757)